Document Detail

Detection of ozone toxicity during continuous exercise via the effective dose concept.
MedLine Citation:
PMID:  7263448     Owner:  NLM     Status:  MEDLINE    
In evaluating O3 toxicity in humans, the effective dose, expressed as the simple product of concentration, exposure duration and ventilation volume (VE), has been applied only to resting or intermittent exercise (IE) exposures. In the present study, we examined the validity of effective dose in predicting pulmonary function impairment when effective dose was determined both as a simple product and as a weighted function via multiple regression. Eight trained male subjects (ages 22-46) completed 18 protocols, including exposures (via mouthpiece) to filtered air and three levels of O3 concentration (0.20, 0.30, and 0.40 ppm), while exercising continuously for durations ranging from 30 to 80 min. The O3 effective dose was significantly related to pulmonary function impairment and exercise ventilatory pattern alteration. Multiple regression analysis, however, substantiated the predominant importance of O3 concentration, with the threshold for O3 toxicity during exercise at a moderately heavy work load [approximately 65% maximum O2 uptake (VO2 max)] shown to be between 0.20 and 0.30 ppm. Although considerable individual variability in O3 toxicity response was noted, group mean responses in our continuous exercise mouthpiece exposures were similar to those previously observed with IE chamber exposures. Thus while the effective dose concept has notable deficiencies in predicting the individual degree of O3 toxicity, it remains a useful approach and warrants further investigation.
W C Adams; W M Savin; A E Christo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  51     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-22     Citation Subset:  IM; S    
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MeSH Terms
Middle Aged
Ozone / toxicity*
Physical Exertion*
Respiration / drug effects*
Respiratory Function Tests
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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