Document Detail

Detection of optic pathway misrouting in the human albino neonate.
MedLine Citation:
PMID:  1775217     Owner:  NLM     Status:  MEDLINE    
The diagnosis of albinism is indicated by the presence of visual pathway misrouting in which temporal retinal fibers erroneously decussate at the optic chiasm disrupting the normal topographical distribution of retinal geniculate-cortical projections. Detection of misrouted fibers is effected by non-invasive electrophysiological assessment of the topographical representation of the visual evoked potential (VEP) following full field monocular stimulation. By combining appropriate state defined neonatal recording procedures with the albino VEP test paradigm, the presence of aberrant optic pathway projections was detected in a five-day-old full-term infant. The electrophysiological signature pathognomonic to albinism was observed within a long (300 ms) latency window of an otherwise normal neonatal luminance flash response. The results of this study indicate that the VEP misrouting test can be extended to reliable albino diagnosis within the neonatal period.
P Apkarian; P G Eckhardt; M J van Schooneveld
Related Documents :
1775217 - Detection of optic pathway misrouting in the human albino neonate.
17937207 - Gaseous emboli detection based on a dual-wavelet transform analysis.
20424017 - Preverbal infants' sensitivity to synaesthetic cross-modality correspondences.
4080657 - Guidelines for illustrations.
23454087 - Cimetidine-associated patent ductus arteriosus is mediated via a cytochrome p450 mechan...
6478547 - Infantile colic: incidence and treatment in a norfolk community.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropediatrics     Volume:  22     ISSN:  0174-304X     ISO Abbreviation:  Neuropediatrics     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-03-04     Completed Date:  1992-03-04     Revised Date:  2008-01-16    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
The Netherlands Ophthalmic Research Institute, Amsterdam.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Albinism / diagnosis*,  physiopathology
Evoked Potentials, Visual*
Functional Laterality
Infant, Newborn
Visual Pathways / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A nationwide survey on transient hyperammonemia in newborn infants in Japan: prognosis of life and n...
Next Document:  EEG findings in hypomelanosis of Ito.