Document Detail


Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters.
MedLine Citation:
PMID:  19671931     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The long-chain omega-3 fatty acids (n-3 FA) eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA) have beneficial health effects, but the molecular mediators of these effects are not well characterized. Oxygenated n-3 FAs (oxylipins) may be an important class of mediators. Members of this chemical class include epoxides, alcohols, diols, and ketones, many of which have bioactivity in vitro. Neither the presence of n-3 oxylipins in human plasma nor the effect of n-3 FA ingestion on their levels has been documented. We measured plasma oxylipins derived from both the n-3 and n-6 FA classes in healthy volunteers (n = 10) before and after 4 weeks of treatment with prescription n-3 FA ethyl esters (4 g/day). At baseline, EPA and DHA oxylipins were detected in low (1-50 nM) range, with alcohols > epoxides >or= diols. Treatment increased n-3 oxylipin levels 2- to 5-fold and reduced selected n-6 oxylipins by approximately 20%. This is the first documentation that endogenous n-3 oxylipin levels can be modulated by n-3 FA treatment in humans. The extent to which the beneficial cardiovascular effects of n-3 FAs are mediated by increased n-3 and/or reduced n-6 oxylipin levels remains to be explored.
Authors:
Gregory C Shearer; William S Harris; Theresa L Pedersen; John W Newman
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-08-11
Journal Detail:
Title:  Journal of lipid research     Volume:  51     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-10-20     Revised Date:  2011-08-03    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2074-81     Citation Subset:  IM    
Affiliation:
Cardiovascular Health Research Center, Sanford Research/USD, Sioux Falls, SD, USA. greg.shearer@usd.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohols / blood,  metabolism
Biological Transport / drug effects
Epoxy Compounds / blood,  metabolism
Esters
Fatty Acids, Omega-3 / blood,  chemistry*,  pharmacology*
Female
Humans
Ketones / blood,  metabolism
Male
Middle Aged
Oxylipins / blood*,  chemistry*,  metabolism
Young Adult
Grant Support
ID/Acronym/Agency:
2-P20-RR016479/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Alcohols; 0/Epoxy Compounds; 0/Esters; 0/Fatty Acids, Omega-3; 0/Ketones; 0/Oxylipins
Comments/Corrections

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