Document Detail

Detection of obestatin in seminal plasma and its relationship with ghrelin and semen parameters.
MedLine Citation:
PMID:  21474128     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To investigate the occurrence of ghrelin and obestatin in human semen. DESIGN: Prospective study. SETTING: University, center for research and therapy of male infertility. PATIENT(S): 112 consecutively selected men. INTERVENTION(S): Family history, clinical and physical examination, radioimmunoassay for ghrelin and obestatin determinations, semen analysis, annexinV/propidium iodide assay. MAIN OUTCOME MEASURE(S): Ghrelin and obestatin detected in the semen and relationships with semen parameters and conditions influencing semen quality (smoking, varicocele, ex varicocele, leukocytospermia). RESULT(S): The levels of both peptides in semen were higher versus serum. Linear correlations between ghrelin and obestatin levels in serum and in semen were observed. Serum ghrelin levels were negatively correlated with the men's ages. Semen obestatin levels were positively correlated with sperm concentration and motility. Obestatin levels were decreased in the semen of smokers and in the presence of leukocytospermia. CONCLUSION(S): This is the first study on the presence of obestatin in human semen and its relationship with sperm concentration and motility, suggesting a possible role of the peptide in controlling cell proliferation and survival. Further investigations are required to explore the exact role of obestatin and ghrelin in human semen.
Elena Moretti; Giulia Collodel; Francesca Iacoponi; Michela Geminiani; Nicola Antonio Pascarelli; Stella Campagna; Beatrice Franci; Natale Figura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-5
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Biomedical Sciences, Applied Biology Section, University of Siena, Siena, Italy; Interdepartmental Centre for Research and Therapy of Male Infertility, University of Siena, Sienna, Italy.
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