| Detection of noncritical coronary stenosis at rest without recourse to exercise or pharmacological stress. | |
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MedLine Citation:
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PMID: 11790704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Currently, the detection of noncritical coronary stenoses requires some form of stress. We hypothesized that these stenoses can be detected at rest without recourse to stress by assessing adaptive changes that occur distally in the microcirculation. METHODS AND RESULTS: Phasic changes in myocardial video intensity (VI) were measured at rest with continuous high-mechanical-index (MI) contrast echocardiography in 15 open-chest dogs. Data were acquired at baseline and in the presence of different degrees of noncritical coronary stenosis. In 6 of these dogs, capillary blood volume was also measured at baseline using high-MI intermittent imaging with triggering performed separately at both end diastole and end systole. During continuous high-MI imaging, a significant increase in systolic VI was noted with coronary stenoses that resulted in progressive increases in the systolic/diastolic VI ratio with greater degrees of stenosis (P=0.003), with a mildly quadratic relation noted between the two: y=1.3. 10(-6). x(2)+0.01x+0.32, P<0.001, r=0.76, SEE=0.14. There was no difference in capillary blood volume between end diastole and end systole at baseline. CONCLUSIONS: Capillary blood volume does not change between diastole and systole in vivo. Phasic changes in VI are noted at baseline during high-MI continuous imaging. The systolic component is negligible at baseline but increases with increasing levels of noncritical coronary stenosis because of adaptive changes in the microcirculation distal to the stenosis. Thus, the measurement of phasic changes in myocardial VI has the potential to detect coronary stenosis at rest without recourse to any form of stress. |
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Authors:
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Kevin Wei; Elizabeth Le; Ananda R Jayaweera; Jian-Ping Bin; N Craig Goodman; Sanjiv Kaul |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 105 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-15 Completed Date: 2002-02-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 218-23 Citation Subset: AIM; IM |
Affiliation:
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Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia, Charlottesville, VA 22908, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Stenosis / ultrasonography* Dogs Echocardiography / methods* Kinetics Microcirculation Myocardial Contraction Physical Conditioning, Animal Regional Blood Flow Rest |
| Grant Support | |
ID/Acronym/Agency:
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HL-48890/HL/NHLBI NIH HHS; K08-HL03909/HL/NHLBI NIH HHS; T32-HL07355/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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