Document Detail

Detection of multiple sclerosis from exhaled breath using bilayers of polycyclic aromatic hydrocarbons and single-wall carbon nanotubes.
MedLine Citation:
PMID:  22860162     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A cross-reactive array of polycyclic aromatic hydrocarbons and single wall carbon nanotube bilayers was designed for the detection of volatile organic compounds (tentatively, hexanal and 5-methyl-undecane) that identify the presence of disease in the exhaled breath of patients with multiple sclerosis. The sensors showed excellent discrimination between hexanal, 5-methyl-undecane, and other confounding volatile organic compounds. Results obtained from a clinical study consisting of 51 volunteers showed that the sensors could discriminate between multiple sclerosis and healthy states from exhaled breath samples with 85.3% sensitivity, 70.6% specificity, and 80.4% accuracy. These results open new frontiers in the development of a fast, noninvasive, and inexpensive medical diagnostic tool for the detection and identification of multiple sclerosis. The results could serve also as a launching pad for the discrimination between different subphases or stages of multiple sclerosis as well as for the identification of multiple sclerosis patients who would respond well to immunotherapy.
Radu Ionescu; Yoav Broza; Hila Shaltieli; Dvir Sadeh; Yael Zilberman; Xinliang Feng; Lea Glass-Marmor; Izabella Lejbkowicz; Klaus Müllen; Ariel Miller; Hossam Haick
Publication Detail:
Type:  Journal Article     Date:  2011-09-22
Journal Detail:
Title:  ACS chemical neuroscience     Volume:  2     ISSN:  1948-7193     ISO Abbreviation:  ACS Chem Neurosci     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-08-03     Completed Date:  2012-08-23     Revised Date:  2012-12-21    
Medline Journal Info:
Nlm Unique ID:  101525337     Medline TA:  ACS Chem Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  687-93     Citation Subset:  -    
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