| Detection and monitoring of cardiotoxicity-what does modern cardiology offer? | |
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MedLine Citation:
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PMID: 18197426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: With new anticancer therapies, many patients can have a long life expectancy. Treatment-related comorbidities become an issue for cancer survivors. Cardiac toxicity remains an important side effect of anticancer therapies. Myocardial dysfunction can become apparent early or long after end of therapy and may be irreversible. Detection of cardiac injury is crucial since it may facilitate early therapeutic measures. Traditionally, chemotherapy-induced cardiotoxicity has been detected by measuring changes in left ventricular ejection fraction. This parameter is, however, insensitive to subtle changes in myocardial function as they occur in early cardiotoxicity. DISCUSSION: This review will discuss conventional and modern cardiologic approaches of assessing myocardial function. It will focus on Doppler myocardial imaging, a method which allows to sensitively measure myocardial function parameters like myocardial velocity, deformation (strain), or deformation rate (strain rate) and which has been shown to reliably detect early abnormalities in both regional and global myocardial function in an early stage. Other newer echocardiographic function estimators are based on automated border detection algorithms and ultrasonic integrated backscatter analysis. A further technique to be discussed is dobutamine stress echocardiography. The use of new biomarkers like B-type natriuretic peptide and troponin and less often used imaging techniques like magnetic resonance imaging and computed tomography will also be mentioned. |
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Authors:
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Ruxandra Jurcut; Hans Wildiers; Javier Ganame; Jan D'hooge; Robert Paridaens; Jens-Uwe Voigt |
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Publication Detail:
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Type: Journal Article Date: 2008-01-16 |
Journal Detail:
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Title: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Volume: 16 ISSN: 0941-4355 ISO Abbreviation: Support Care Cancer Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-08 Completed Date: 2008-09-11 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9302957 Medline TA: Support Care Cancer Country: Germany |
Other Details:
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Languages: eng Pagination: 437-45 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Hospital Gasthuisberg, Catholic University Leuven, Herestraat 49, 3000, Leuven, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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adverse effects*,
therapeutic use Biological Markers Echocardiography, Doppler / methods* Heart / drug effects* Heart Diseases / chemically induced*, diagnosis Humans Neoplasms / complications, therapy* Radiation Injuries / etiology, ultrasonography* Survivors |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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