Document Detail

Detection of micro- and nano-sized biocompatible particles in the blood.
MedLine Citation:
PMID:  15332619     Owner:  NLM     Status:  MEDLINE    
The research deals with new scanning electron microscopic evaluations of the interface between blood and explanted temporary vena cava filters from patients affected by blood disorders. The biological tissues adherent to the filter and the small thrombi formed in vivo were detached from the metallic structure of the device, fixed, dehydrated and prepared for the histological and the electron microscopy. The analyses showed that both samples (thrombus and newly formed tissue) contained foreign, in some cases nano-sized, bodies. The chemistry of these particles was different and varied, and unusual compounds containing non-biocompatible elements like bismuth, lead, wolfram, tungsten were also detected. The interaction between these debris travelling in the blood stream and the blood itself leads to suspect that the formation of the thrombus can originate from these inorganic and inert foreign bodies that act as triggering agent of the blood coagulation.
A M Gatti; S Montanari; E Monari; A Gambarelli; F Capitani; B Parisini
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  15     ISSN:  0957-4530     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-08-30     Completed Date:  2004-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  469-72     Citation Subset:  IM    
INFM, Laboratorio dei Biomateriali, Dipartimento di Neuroscienze, Testa Collo, Riabilitazione, Università di Modena e Reggio Emilia, via del Pozzo, 71 41100 Modena, Italy.
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MeSH Terms
Biocompatible Materials / analysis*
Blood Chemical Analysis / methods*
Equipment Failure Analysis / methods
Foreign Bodies / pathology*
Nanotubes / analysis*,  ultrastructure*
Ultrafiltration / instrumentation,  methods*
Vena Cava Filters*
Reg. No./Substance:
0/Biocompatible Materials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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