Document Detail


Detection and masking of spoiled food smells by odor maps in the olfactory bulb.
MedLine Citation:
PMID:  15470134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two major causes of spoiled food smells such as fatty, fishy off-flavors are alkylamines liberated by bacterial actions and aliphatic acids-aldehydes generated by lipid oxidation. Using the method of intrinsic signal imaging, we mapped alkylamine-responsive glomeruli to a subregion of the aliphatic acid-responsive and aldehyde-responsive cluster in the odor maps of rat olfactory bulb. Extracellular single-unit recordings from mitral-tufted cells in the subregion showed that individual cells responded to the alkylamines in addition to acids and aldehydes. Responses of mitral-tufted cells tended to last for a long period (5-88 sec) even after the cessation of the alkylamine stimulation. These results suggest that the subregion is part of the representation of the fatty, fishy odor quality. Fennel and clove, spices known to add flavor and mask the fatty, fishy odor, activated glomeruli in the surrounding clusters and suppressed the alkylamine-induced and acid-aldehyde-induced responses of mitral cells, suggesting that the odor masking is mediated, in part, by lateral inhibitory connections in the odor maps of the olfactory bulb.
Authors:
Yuji K Takahashi; Shin Nagayama; Kensaku Mori
Related Documents :
7455904 - Controlled intragastric ph and cimetidine inhibition of histamine-stimulated gastric ac...
6143394 - The effect of alpha- and beta-receptor blocking agents on gastric acid secretion in gui...
13779674 - The histamine test meal in the rat.
4010464 - Gastric acid and vagus nerve response to gaba agonist baclofen.
2359524 - Glycine antagonists block the induction of long-term potentiation in ca1 of rat hippoca...
12702404 - Synthesis and monolayer characterization of phosphorylated amino acid analogs.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  24     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-07     Completed Date:  2005-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8690-4     Citation Subset:  IM    
Affiliation:
Department of Physiology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amines / pharmacology
Animals
Evoked Potentials
Fish Products
Food*
Male
Neural Inhibition
Odors*
Olfactory Bulb / cytology*,  drug effects,  physiology
Rats
Rats, Wistar
Spices
Chemical
Reg. No./Substance:
0/Amines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels.
Next Document:  Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene.