| Detection of inspiratory resistive loads in double-lung transplant recipients. | |
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MedLine Citation:
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PMID: 12381766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The afferent pathways mediating respiratory load perception are still largely unknown. To assess the role of lung vagal afferents in respiratory sensation, detection of inspiratory resistive loads was compared between 10 double-lung transplant (DLT) recipients with normal lung function and 12 healthy control (Nor) subjects. Despite a similar unloaded and loaded breathing pattern, the DLT group had a significantly higher detection threshold (2.91 +/- 0.5 vs. 1.55 +/- 0.3 cmH(2)O. l(-1). s) and Weber fraction (0.50 +/- 0.1 vs. 0.30 +/- 0.1) compared with the Nor group. These results suggest that inspiratory resistive load detection occurs in the absence of vagal afferent feedback from the lung but that lung vagal afferents contribute to inspiratory resistive load detection response in humans. Lung vagal afferents are not essential to the regulation of resting breathing and load compensation responses. |
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Authors:
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Weiying Zhao; A Daniel Martin; Paul W Davenport |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 93 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-16 Completed Date: 2003-04-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1779-85 Citation Subset: IM |
Affiliation:
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Department of Physical Therapy, University of Florida, Gainesville, Florida 32610, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Resistance* Differential Threshold False Positive Reactions Female Humans Inhalation* Lung Transplantation* Male Middle Aged Psychophysics / methods Reaction Time Reference Values Work of Breathing* |
| Grant Support | |
ID/Acronym/Agency:
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HL-47892/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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