Document Detail

Detection of inspiratory resistive loads in double-lung transplant recipients.
MedLine Citation:
PMID:  12381766     Owner:  NLM     Status:  MEDLINE    
The afferent pathways mediating respiratory load perception are still largely unknown. To assess the role of lung vagal afferents in respiratory sensation, detection of inspiratory resistive loads was compared between 10 double-lung transplant (DLT) recipients with normal lung function and 12 healthy control (Nor) subjects. Despite a similar unloaded and loaded breathing pattern, the DLT group had a significantly higher detection threshold (2.91 +/- 0.5 vs. 1.55 +/- 0.3 cmH(2)O. l(-1). s) and Weber fraction (0.50 +/- 0.1 vs. 0.30 +/- 0.1) compared with the Nor group. These results suggest that inspiratory resistive load detection occurs in the absence of vagal afferent feedback from the lung but that lung vagal afferents contribute to inspiratory resistive load detection response in humans. Lung vagal afferents are not essential to the regulation of resting breathing and load compensation responses.
Weiying Zhao; A Daniel Martin; Paul W Davenport
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  93     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-16     Completed Date:  2003-04-10     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1779-85     Citation Subset:  IM    
Department of Physical Therapy, University of Florida, Gainesville, Florida 32610, USA.
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MeSH Terms
Airway Resistance*
Differential Threshold
False Positive Reactions
Lung Transplantation*
Middle Aged
Psychophysics / methods
Reaction Time
Reference Values
Work of Breathing*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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