Document Detail

Detection of human metapneumovirus in infants with acute respiratory tract infection.
MedLine Citation:
PMID:  21468562     Owner:  NLM     Status:  MEDLINE    
Both respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), a recently discovered respiratory pathogen classified in the Paramyxoviridae family, have been associated with acute respiratory tract infections (ARTI) in infants. The aim of our study was to determine the incidence and clinical features of hMPV infection in infants presenting with ARTI at a tertiary children's hospital in Greece during the 2007-2008 and 2008-2009 winter seasons. Routine nasal swabs were obtained from 127 infants younger than 12 months of age. The specimens were tested for the presence of hMPV and RSV antigens using validated enzyme-linked immunoassays. The mean age of the studied infants was 3 months (range 19 days to 12 months). hMPV was detected in 8 (6.3%) children, 4 boys and 4 girls, while RSV was detected in 39 (30.7%) children, 22 boys and 17 girls. In 7 children, hMPV was identified as a unique viral pathogen, while only 1 child was co-infected with hMPV and RSV. Bronchiolitis was diagnosed in all hMPV-positive cases, while only two cases required hospitalization and supplemental oxygen therapy. Our results provide further evidence of the importance of hMPV as a pathogen associated with community-acquired ARTI in infants in Greece.
Ioannis N Mammas; Chryssie Koutsaftiki; Elisabeth Nika; Fotini Vagia; Apostolos Zaravinos; Kostas N Priftis; Aliki Voyatzi; Maria Theodoridou; Nikolaos Myriokefalitakis; Demetrios A Spandidos
Publication Detail:
Type:  Journal Article     Date:  2011-01-03
Journal Detail:
Title:  Molecular medicine reports     Volume:  4     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-04-06     Completed Date:  2011-07-12     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
First Department of Paediatrics, Penteli Children's Hospital, Palaia Penteli, Athens 15236, Greece.
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MeSH Terms
Acute Disease
Infant, Newborn
Metapneumovirus / isolation & purification*
Respiratory Tract Infections / pathology,  virology*

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