Document Detail


Detection of histologically proven peritoneal carcinomatosis with fused 18F-FDG-PET/MDCT.
MedLine Citation:
PMID:  18248928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate peritoneal carcinomatosis in patients with gastrointestinal and gynecologic malignancies and to assess the diagnostic role for 18-FDG-PET and MDCT alone in comparison to the diagnostic accuracy of fused 18F-FDG-PET/MDCT by using surgical and histopathological findings as the standard of reference. METHODS AND SUBJECTS: Sixty-two patients (13 males, 49 females; age range 43-81; mean age, 62 years with suspected peritoneal carcinomatosis were reviewed for the presence of peritoneal lesions on 18F-FDG-PET/MDCT scans (Discovery LS, GE Medical Systems). The results were compared with the histological findings at laparatomy. Thirty-one patients had peritoneal metastases, while 31 patients had negative histological findings at laparotomy. RESULTS: CT detected peritoneal seeding in 26/31 patients, 18F-FDG-PET in 25/31 patients, and 18F-FDG-PET/MDCT in 30/31 patients, for a sensitivity of 88%, 88%, and 100%, respectively. False-positive findings were seen in MDCT in one patient, in 18F-FDG-PET in two patients, and in 18F-MDCT-PET/MDCT in one patient, for a specificity of 97%, 94%, and 97%, respectively. CONCLUSION: Fused 18F-FDG-PET/MDCT is superior to MDCT and 18F-FDG-PET alone for the detection of peritoneal carcinomatosis especially in small lesions and it offers exact anatomic information for surgical treatment.
Authors:
Albert Dirisamer; Wolfgang Schima; Martin Heinisch; Michael Weber; Hans Peter Lehner; Joerg Haller; Werner Langsteger
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Publication Detail:
Type:  Journal Article     Date:  2008-01-14
Journal Detail:
Title:  European journal of radiology     Volume:  69     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  536-41     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, St. Vincent's Hospital, Seilerstaette 4, 4010 Linz, Austria. albert.dirisamer@meduniwien.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Fluorodeoxyglucose F18 / diagnostic use*
Humans
Image Interpretation, Computer-Assisted / methods*
Male
Middle Aged
Peritoneal Neoplasms / diagnosis*
Positron-Emission Tomography / methods*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Subtraction Technique*
Tomography, X-Ray Computed / methods*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

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