Document Detail

Detection of high-mass biomolecules in Fourier transform ion cyclotron resonance mass spectrometry: theoretical and experimental investigations.
MedLine Citation:
PMID:  8017637     Owner:  NLM     Status:  MEDLINE    
A simple modification to an ion cyclotron resonance (ICR) cell for detection of high-mass ions with large spatial and kinetic energy distributions is described. The modification consists of a copper wire positioned inside the ICR cell running parallel to the magnetic field lines. The wire acts as an ion guide to position the ions at the exact center of the ion cell. Ion trajectories are calculated using SIMION, and the predictions based on the calculations are compared with the experimental results. The results presented in this paper show that the ion-guide ICR cell can be used to detect singly charged biomolecule ions of up to 157,000 Da.
T Solouki; K J Gillig; D H Russell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Analytical chemistry     Volume:  66     ISSN:  0003-2700     ISO Abbreviation:  Anal. Chem.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-07-28     Completed Date:  1994-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1583-7     Citation Subset:  IM    
Department of Chemistry, Texas A&M University, College Station 77843.
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MeSH Terms
Fourier Analysis*
Macromolecular Substances
Mass Spectrometry / methods*
Molecular Weight
Reg. No./Substance:
0/Macromolecular Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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