| Detection of hibernate myocardium by 99mTc sestamibi gated SPECT during low-dose dobutamine infusion plus nitrate in patients with first acute myocardial infarction. | |
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MedLine Citation:
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PMID: 16096579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate the role of Tc-MIBI gated SPECT imaging following the administration of low-dose dobutamine plus nitrate (LDD+nitrate) in the assessment of left ventricular function and the perfusion of hibernate myocardial tissue. METHODS: The study group comprised 29 patients diagnosed as having acute myocardial infarction. In the first month post-infarction, Tc-MIBI gated SPECT imaging was performed in all patients at rest-dobutamine stress and LDD+nitrate. Ejection fraction, end diastolic volume (EDV), end systolic volume (ESV), stroke volume, volume, extent score, and reversibility score values were calculated. RESULTS: The findings of Tc-MIBI gated SPECT imaging following the administration of LDD+nitrate and the rest Tc-MIBI gated SPECT findings revealed that while the levels of ejection fraction (P=0.004) and reversibility score (P=0.000) increased significantly, there was a significant decrease in EDV (P=0.001), ESV (P=0.001), volume (P=0.017), stroke volume (P=0.257) and extent score (P=0.039) values. CONCLUSION: The use of Tc-MIBI gated SPECT concomitantly with the administration of LDD+nitrate is useful in the determination of myocardial hibernation in patients with left ventricular failure following acute myocardial infarction. |
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Authors:
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Emre Entok; Yuksel Cavusoglu; Eser Kaya; Erkan Vardareli; Bilgin Timuralp |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 26 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-12 Completed Date: 2005-12-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 765-72 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Osmangazi University Medical Faculty, 26480 Eskişehir, Turkey. e_entok@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Dobutamine / administration & dosage, diagnostic use* Female Humans Infusions, Intravenous Male Middle Aged Myocardial Infarction / complications, radionuclide imaging* Myocardial Stunning / complications, radionuclide imaging Nitrates / administration & dosage, diagnostic use* Prognosis Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Technetium Tc 99m Sestamibi / diagnostic use* Tomography, Emission-Computed, Single-Photon / methods* Ventricular Dysfunction, Left / etiology, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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