Document Detail

Detection of hibernate myocardium by 99mTc sestamibi gated SPECT during low-dose dobutamine infusion plus nitrate in patients with first acute myocardial infarction.
MedLine Citation:
PMID:  16096579     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the role of Tc-MIBI gated SPECT imaging following the administration of low-dose dobutamine plus nitrate (LDD+nitrate) in the assessment of left ventricular function and the perfusion of hibernate myocardial tissue. METHODS: The study group comprised 29 patients diagnosed as having acute myocardial infarction. In the first month post-infarction, Tc-MIBI gated SPECT imaging was performed in all patients at rest-dobutamine stress and LDD+nitrate. Ejection fraction, end diastolic volume (EDV), end systolic volume (ESV), stroke volume, volume, extent score, and reversibility score values were calculated. RESULTS: The findings of Tc-MIBI gated SPECT imaging following the administration of LDD+nitrate and the rest Tc-MIBI gated SPECT findings revealed that while the levels of ejection fraction (P=0.004) and reversibility score (P=0.000) increased significantly, there was a significant decrease in EDV (P=0.001), ESV (P=0.001), volume (P=0.017), stroke volume (P=0.257) and extent score (P=0.039) values. CONCLUSION: The use of Tc-MIBI gated SPECT concomitantly with the administration of LDD+nitrate is useful in the determination of myocardial hibernation in patients with left ventricular failure following acute myocardial infarction.
Emre Entok; Yuksel Cavusoglu; Eser Kaya; Erkan Vardareli; Bilgin Timuralp
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  26     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-12     Completed Date:  2005-12-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  765-72     Citation Subset:  IM    
Department of Nuclear Medicine, Osmangazi University Medical Faculty, 26480 Eskişehir, Turkey.
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MeSH Terms
Dobutamine / administration & dosage,  diagnostic use*
Infusions, Intravenous
Middle Aged
Myocardial Infarction / complications,  radionuclide imaging*
Myocardial Stunning / complications,  radionuclide imaging
Nitrates / administration & dosage,  diagnostic use*
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Technetium Tc 99m Sestamibi / diagnostic use*
Tomography, Emission-Computed, Single-Photon / methods*
Ventricular Dysfunction, Left / etiology,  radionuclide imaging*
Reg. No./Substance:
0/Nitrates; 0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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