Document Detail


Detection of herpesviruses and parvovirus B19 in gastric and intestinal mucosa of chronic fatigue syndrome patients.
MedLine Citation:
PMID:  19414405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Human herpesvirus-6 (HHV-6), Epstein-Barr virus and parvovirus B19 have been suggested as etiological agents of chronic fatigue syndrome but none of these viruses is consistently detected in all patients. However, active viral infections may be localized in specific tissues, and, therefore, are not easily detectable. The aim of this study was to investigate the presence of HHV-6, HHV-7, EBV and parvovirus B19 in the gastro-intestinal tract of CFS patients. PATIENTS AND METHODS: Using real-time PCR, viral DNA loads were quantified in gastro-intestinal biopsies of 48 CFS patients and 35 controls. RESULTS: High loads of HHV-7 DNA were detected in most CFS and control biopsies. EBV and HHV-6 were detected in 15-30% of all biopsies. Parvovirus B19 DNA was detected in 40% of the patients versus less than 15% of the controls. CONCLUSION: Parvovirus B19 may be involved in the pathogenesis of CFS, at least for a subset of patients. The gastro-intestinal tract appears as an important reservoir of infection for several potentially pathogenic viruses.
Authors:
Marc Frémont; Kristine Metzger; Hamada Rady; Jan Hulstaert; Kenny De Meirleir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  23     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-05-05     Completed Date:  2009-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  209-13     Citation Subset:  IM    
Affiliation:
Protea Biopharma, Z.1-Researchpark 100, 1731 Zellik, Belgium. mfremont@proteabiopharma.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
DNA Primers / chemistry
DNA, Viral / metabolism
Fatigue Syndrome, Chronic / metabolism,  virology*
Female
Gastric Mucosa / virology*
Gene Expression Regulation, Viral*
Herpesviridae / metabolism*
Humans
Intestinal Mucosa / virology*
Male
Middle Aged
Parvovirus B19, Human / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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