| Detection of hepatocellular carcinoma: comparison of ferumoxides-enhanced and gadolinium-enhanced dynamic three-dimensional volume interpolated breath-hold MR imaging. | |
| | |
MedLine Citation:
|
PMID: 15449000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose was to compare the diagnostic accuracy of ferumoxides-enhanced MR imaging and gadolinium-enhanced dynamic MR imaging using three-dimensional (3D) volume interpolated breath-hold examination (VIBE) for the detection of hepatocellular carcinoma (HCC). Forty-nine patients with 61 HCCs, who underwent ferumoxides-enhanced and gadolinium-enhanced dynamic MR imaging, were included prospectively in this study. Ferumoxides-enhanced MR imaging was performed 24 h after completion of the dynamic study using 3D-VIBE. Three radiologists independently interpreted the images. The diagnostic accuracy was evaluated using the receiver-operating characteristic method, and the sensitivity of each imaging technique was compared using McNemar's test. The mean diagnostic accuracy of dynamic MR imaging (Az=0.95) was higher than that of ferumoxides-enhanced MR imaging (Az=0.90), but failed to reach a statistical significance (P=0.057). The mean sensitivity of dynamic MR imaging (90.7%) was significantly superior to that of ferumoxides-enhanced MR imaging (80.9%, P=0.03). Furthermore, for lesions smaller than 15 mm, the mean sensitivity of dynamic MR imaging was significantly higher than that of ferumoxides-enhanced MR imaging (85.2% vs. 69.2%, P<0.05). Dynamic MR imaging showed a trend toward better diagnostic accuracy for than ferumoxides-enhanced MR imaging for the detection of HCCs. |
| | |
Authors:
|
Hyo-Sung Kwak; Jeong-Min Lee; Young-Kon Kim; Young Hwan Lee; Chong-Soo Kim |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2004-09-22 |
Journal Detail:
|
Title: European radiology Volume: 15 ISSN: 0938-7994 ISO Abbreviation: Eur Radiol Publication Date: 2005 Jan |
Date Detail:
|
Created Date: 2005-01-13 Completed Date: 2005-05-12 Revised Date: 2013-04-11 |
Medline Journal Info:
|
Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 140-7 Citation Subset: IM |
Affiliation:
|
Department of Diagnostic Radiology, Chonbuk National University Medical School, Chon-ju, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Carcinoma, Hepatocellular / diagnosis* Contrast Media Dextrans Female Ferumoxytol Gadolinium DTPA / diagnostic use Humans Imaging, Three-Dimensional Iron / diagnostic use Liver Neoplasms / diagnosis* Magnetic Resonance Imaging / methods* Magnetite Nanoparticles Male Middle Aged Oxides / diagnostic use Predictive Value of Tests Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Magnetite Nanoparticles; 0/Oxides; 1317-61-9/Ferumoxytol; 7439-89-6/Iron; 80529-93-7/Gadolinium DTPA; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adrenal gland and adrenal mass calcification.
Next Document: Multidetector computed tomography-guided treatment strategy in patients with non-ST elevation acute ...