| Detection of hepatic metastases from cancers of the gastrointestinal tract by using noninvasive imaging methods (US, CT, MR imaging, PET): a meta-analysis. | |
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MedLine Citation:
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PMID: 12202709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To perform a meta-analysis to compare current noninvasive imaging methods (ultrasonography [US], computed tomography [CT], magnetic resonance [MR] imaging, and (18)F fluorodeoxyglucose [FDG] positron emission tomography [PET]) in the detection of hepatic metastases from colorectal, gastric, and esophageal cancers. MATERIALS AND METHODS: A MEDLINE literature search and review of article bibliographies and our institutional charts of patients with colorectal cancer identified data with histopathologic correlation or at least 6 months of patient follow-up. Two authors independently abstracted data sets and excluded data without contingency tables or data published more than once. Summary-weighted estimates of sensitivity were obtained and stratified according to specificity of less than 85% or 85% and higher. A covariate analysis was used to evaluate the influence of patient- or study-related factors on sensitivity. RESULTS: Among 111 data sets, nine US (509 patients), 25 CT (1,747 patients), 11 MR imaging (401 patients), and nine PET (423 patients) data sets met the inclusion criteria. In studies with a specificity higher than 85%, the mean weighted sensitivity was 55% (95% CI: 41, 68) for US, 72% (95% CI: 63, 80) for CT, 76% (95% CI: 57, 91) for MR imaging, and 90% (95% CI: 80, 97) for FDG PET. Results of pairwise comparison between imaging modalities demonstrated a greater sensitivity of FDG PET than US (P =.001), CT (P =.017), and MR imaging (P =.055). CONCLUSION: At equivalent specificity, FDG PET is the most sensitive noninvasive imaging modality for the diagnosis of hepatic metastases from colorectal, gastric, and esophageal cancers. |
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Authors:
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Karen Kinkel; Ying Lu; Marcus Both; Robert S Warren; Ruedi F Thoeni |
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Publication Detail:
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Type: Comparative Study; Journal Article; Meta-Analysis |
Journal Detail:
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Title: Radiology Volume: 224 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-08-30 Completed Date: 2002-10-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 748-56 Citation Subset: AIM; IM |
Copyright Information:
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Copyright RSNA, 2002 |
Affiliation:
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Department of Radiology, Geneva University Hospital, Rue Micheli-du-Crest 24, Switzerland. karen.kinkel@hcuge.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Colorectal Neoplasms
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pathology Esophageal Neoplasms / pathology Gastrointestinal Neoplasms / pathology* Humans Liver Neoplasms / diagnosis*, secondary*, ultrasonography Magnetic Resonance Imaging Sensitivity and Specificity Stomach Neoplasms / pathology Tomography, Emission-Computed Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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