Document Detail

Detection of haematoporphyrin derivative and haematoporphyrin excited states in cell environments.
MedLine Citation:
PMID:  2968837     Owner:  NLM     Status:  MEDLINE    
The photosensitiser currently used in the photodynamic therapy of cancer is haematoporphyrin derivative. Pulsed laser studies of this material and also of the "parent" molecule haematoporphyrin in polyoma-transformed fibroblast cells have now been studied. We report, for the first time, the observation of the triplet absorption of these sensitisers in cells. The corresponding triplet-triplet spectra are red shifted compared to aqueous buffer, lambda(max) 420 nm shifts to 460 nm. We also report our failure to observe singlet oxygen from the cells even though the triplet state can be seen to interact with the oxygen and even though singlet oxygen can be readily detected with the same sensitisers bound to serum albumin.
T G Truscott; A J McLean; A M Phillips; W S Foulds
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  41     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-12     Completed Date:  1988-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
Department of Chemistry, Paisley College of Technology, Scotland.
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MeSH Terms
Cell Line
Hematoporphyrin Derivative
Oxygen / analysis
Reg. No./Substance:
0/Hematoporphyrins; 68335-15-9/Hematoporphyrin Derivative; 7782-44-7/Oxygen

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