Document Detail

Detection of glaucomatous damage using multifocal ERG.
MedLine Citation:
PMID:  16329750     Owner:  NLM     Status:  MEDLINE    
The first-order kernel analysis in multifocal electroretinogram (mfERG) using low contrast stimulation is suggested as a way to detect the inner retinal responses in animal studies. In this case report, this protocol is applied to human patients with glaucoma to demonstrate the possibility of using mfERG as a tool to detect glaucomatous damage. Two patients with glaucoma were recruited and had mfERG measurements with the 103-scaled hexagonal stimulus pattern at low (50 per cent) contrast. Their responses were analysed and compared with those from normal subjects with the mfERG measured under the same condition. In the normal subjects, there were obvious oscillatory components on the ascending and descending limbs of the first-order kernel response to 50 per cent contrast. In the glaucomatous patients, the oscillatory component on the descending limb was obviously diminished. In addition, this component was significantly diminished in the quadrant with a glaucomatous visual field defect. This suggests that the low-contrast stimulation condition in mfERG measurement may provide a good way to detect glaucomatous damage and this may help in clinical diagnosis of glaucoma.
Henry Ho-Lung Chan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical & experimental optometry : journal of the Australian Optometrical Association     Volume:  88     ISSN:  0816-4622     ISO Abbreviation:  Clin Exp Optom     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-06     Completed Date:  2006-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703442     Medline TA:  Clin Exp Optom     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  410-4     Citation Subset:  IM    
School of Optometry, Hong Kong Polytechnic University, Hong Kong SAR, China.
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MeSH Terms
Case-Control Studies
Electroretinography / methods*
Glaucoma / diagnosis*,  physiopathology
Visual Fields

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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