| Detection of free fatty acids following a conditioned taste aversion in rats. | |
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MedLine Citation:
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PMID: 16448678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A gustatory transduction mechanism for free fatty acids (FFAs) has been described in isolated rat taste receptor cells; however, the ability of behaving rats to detect FFAs has not been characterized. Through conditioned taste aversion (CTA) methodology, this study defines the ability of rats to detect and avoid the two principal FFA components of corn oil, linoleic and oleic acid. Following taste aversion conditioning, rats avoided both linoleic and oleic acid at greater than or equal to 66 muM and failed to avoid either 44 muM linoleic or oleic acid. Rats demonstrated generalized avoidances between 88 muM linoleic and oleic acid irrespective of presenting the FFAs as either unesterified acids dissolved in 5 mM ethanol or aqueous sodium salts, sodium linoleate and sodium oleate. Following a CTA to linoleic acid, rats did not show generalized avoidance of NaCl or ethanol, two potentially concomitant tastants in the oral cavity. A CTA to linoleic or oleic acid did produce a generalized avoidance to the other FFA. These results support the ability of rats to detect linoleic and oleic acid (>44 muM) and suggest that the two FFAs share common orosensory properties. Furthermore, it is unlikely that the detection of the FFAs is due to an enhancement of other concomitant tastants such as saliva or the delivery solution. |
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Authors:
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Danielle N McCormack; Virginia L Clyburn; David W Pittman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-01-30 |
Journal Detail:
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Title: Physiology & behavior Volume: 87 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-13 Completed Date: 2006-05-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 582-94 Citation Subset: IM |
Affiliation:
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Department of Psychology, Wofford College, 429 N. Church St., Spartanburg, SC 29303, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avoidance Learning / physiology* Central Nervous System Depressants / pharmacology Cues Ethanol / pharmacology Fatty Acids, Nonesterified / pharmacology* Generalization, Stimulus Linoleic Acid / pharmacology Male Oleic Acid / pharmacology Rats Rats, Sprague-Dawley Sodium Chloride / pharmacology Stimulation, Chemical Taste / drug effects, physiology* Taste Threshold / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Fatty Acids, Nonesterified; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 64-17-5/Ethanol; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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