| Detection of fetal lactate with two-dimensional-localized proton magnetic resonance spectroscopy. | |
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MedLine Citation:
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PMID: 15516455 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Antenatal surveillance is inefficient for accurately detecting fetal compromise. A noninvasive technique for assessing fetal metabolic status would be useful for clinical management. CASE: Fetal magnetic resonance spectroscopy was performed at 20 weeks in a pregnancy complicated by severe intrauterine growth restriction to determine if lactate, a metabolite associated with fetal hypoxia, was present. Two-dimensional, single-slice proton magnetic resonance spectroscopy was carried out at 1.5 T using a volume-selective, double-spin echo technique. Lactate was detected in fetal back muscle. Fetal death occurred the next day. CONCLUSIONS: Although this initial report is purely experimental, further development of this technique may prove to be a valuable noninvasive tool in the management of suspected fetal hypoxia. |
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Authors:
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Julian N Robinson; Jane Cleary-Goldman; Fernando Arias-Mendoza; Jaime Cruz-Lobo; Clare Tempany; Robert V Mulkern; Bruce B Feinberg; Truman R Brown |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 104 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-01 Completed Date: 2005-01-04 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1208-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York, USA. JNRobinson@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Death Fetal Growth Retardation / diagnosis Gestational Age Humans Lactates / analysis* Magnetic Resonance Spectroscopy* Metabolism, Inborn Errors / diagnosis* Pregnancy Prenatal Diagnosis / methods Risk Assessment Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Lactates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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