Document Detail

Detection of fetal lactate with two-dimensional-localized proton magnetic resonance spectroscopy.
MedLine Citation:
PMID:  15516455     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Antenatal surveillance is inefficient for accurately detecting fetal compromise. A noninvasive technique for assessing fetal metabolic status would be useful for clinical management. CASE: Fetal magnetic resonance spectroscopy was performed at 20 weeks in a pregnancy complicated by severe intrauterine growth restriction to determine if lactate, a metabolite associated with fetal hypoxia, was present. Two-dimensional, single-slice proton magnetic resonance spectroscopy was carried out at 1.5 T using a volume-selective, double-spin echo technique. Lactate was detected in fetal back muscle. Fetal death occurred the next day. CONCLUSIONS: Although this initial report is purely experimental, further development of this technique may prove to be a valuable noninvasive tool in the management of suspected fetal hypoxia.
Julian N Robinson; Jane Cleary-Goldman; Fernando Arias-Mendoza; Jaime Cruz-Lobo; Clare Tempany; Robert V Mulkern; Bruce B Feinberg; Truman R Brown
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  104     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-01     Completed Date:  2005-01-04     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1208-10     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Columbia Presbyterian Medical Center, New York, New York, USA.
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MeSH Terms
Fetal Death
Fetal Growth Retardation / diagnosis
Gestational Age
Lactates / analysis*
Magnetic Resonance Spectroscopy*
Metabolism, Inborn Errors / diagnosis*
Prenatal Diagnosis / methods
Risk Assessment
Sensitivity and Specificity
Reg. No./Substance:

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