Document Detail

Detection of expiratory flow limitation during exercise in COPD patients.
MedLine Citation:
PMID:  9074955     Owner:  NLM     Status:  MEDLINE    
The negative expiratory pressure (NEP) method was used to detect expiratory flow limitation at rest and at different exercise levels in 4 normal subjects and 14 patients with chronic obstructive pulmonary disease (COPD). This method does not require performance of forced expirations, nor does it require use of body plethysmography. It consists in applying negative pressure (-5 cmH2O) at the mouth during early expiration and comparing the flow-volume curve of the ensuing expiration with that of the preceding control breath. Subjects in whom application of NEP does not elicit an increase in flow during part or all of the tidal expiration are considered flow limited. The four normal subjects were not flow limited up to 90% of maximal exercise power output (Wmax). Five COPD patients were flow limited at rest, 9 were flow limited at one-third Wmax, and 12 were flow limited at two-thirds Wmax. Whereas in all patients who were flow limited at rest the maximal O2 uptake was below the normal limits, this was not the case in most of the other patients. In conclusion, NEP provides a rapid and reliable method to detect expiratory flow limitation at rest and during exercise.
N G Koulouris; I Dimopoulou; P Valta; R Finkelstein; M G Cosio; J Milic-Emili
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  82     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-27     Completed Date:  1997-06-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  723-31     Citation Subset:  IM    
Meakins-Christie Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Exercise / physiology*
Lung Diseases, Obstructive / physiopathology*
Middle Aged
Pulmonary Ventilation / physiology*
Comment In:
J Appl Physiol (1985). 1997 Mar;82(3):721-2   [PMID:  9074954 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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