| Detection of experimental hepatic tumors using long circulating superparamagnetic particles. | |
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MedLine Citation:
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PMID: 11176257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: To evaluate the potential of an iron oxide-based MR contrast agent for the detection and delineation of experimental liver tumors during the early vascular phase of the compound. METHODS: Superparamagnetic blood pool agent (SBPA) was administered intravenously to rabbits bearing VX2 tumors. Images were acquired before the injection, immediately after, and 1 or 3 weeks later. The variations of signal intensity were measured in the tumors and in several tissues for various T1-weighted spin-echo, T2-weighted fast spin-echo, and T2-weighted gradient-recalled-echo sequences. RESULTS: Fourteen and 12 of the 16 tumors were detected immediately after SBPA injection using, respectively, the T2-weighted fast spin-echo and T2-weighted gradient-recalled-echo sequences. A significant decrease in signal intensity was observed in well-perfused organs, and blood signal was abolished even at the lowest injected dose and using a T1-weighted sequence. In the late phase, the loss in signal intensity of the liver was even more pronounced. CONCLUSION: The dominant T2 effect of SBPA induces an increase in the tumor-to-liver and tumor-to-blood contrast during the vascular phase, improving the detection of the tumors and allowing the distinction between small lesions and vessels through plane. This effect on the liver signal persists for several days because of the incorporation of SBPA in the reticuloendothelial system. |
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Authors:
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Y Sayegh; S Pochon; J P Vallée; M Becker; F Lazeyras; H Tournier; R Hyacinthe; X Fouillet; F Terrier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 36 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-23 Completed Date: 2001-06-07 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 15-21 Citation Subset: IM |
Affiliation:
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Départment de Radiologie, H pital Universitaire de Genéve, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media* Ferric Compounds / diagnostic use* Ferrosoferric Oxide Liver Neoplasms / pathology* Magnetic Resonance Imaging Neoplasms, Experimental / pathology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Ferric Compounds; 0/superparamagnetic blood pool agent; 1317-61-9/Ferrosoferric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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