Document Detail


Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase - United States, 2010.
MedLine Citation:
PMID:  20577157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During January-June 2010, three Enterobacteriaceae isolates carrying a newly described resistance mechanism, the New Delhi metallo-beta-lactamase (NDM-1), were identified from three U.S. states at the CDC antimicrobial susceptibility laboratory. This is the first report of NDM-1 in the United States, and the first report of metallo-beta-lactamase carriage among Enterobacteriaceae in the United States. These isolates, which include an Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae, carry blaNDM-1, which confers resistance to all beta-lactam agents except aztreonam (a monobactam antimicrobial); all three isolates were aztreonam resistant, presumably by a different mechanism. In the United Kingdom, where these organisms are increasingly common, carriage of Enterobacteriaceae containing blaNDM-1 has been closely linked to receipt of medical care in India and Pakistan. All three U.S. isolates were from patients who received recent medical care in India.
Authors:
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  MMWR. Morbidity and mortality weekly report     Volume:  59     ISSN:  1545-861X     ISO Abbreviation:  MMWR Morb. Mortal. Wkly. Rep.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-25     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802429     Medline TA:  MMWR Morb Mortal Wkly Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  750     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Carbapenems / pharmacology
Drug Resistance, Bacterial
Enterobacter cloacae / drug effects,  enzymology*,  isolation & purification
Escherichia coli / drug effects,  enzymology*,  isolation & purification
Humans
India
Klebsiella pneumoniae / drug effects,  enzymology*,  isolation & purification
United States
beta-Lactamases / analysis*
Chemical
Reg. No./Substance:
0/Carbapenems; EC 3.5.2.6/beta-Lactamases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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