| Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase - United States, 2010. | |
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MedLine Citation:
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PMID: 20577157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During January-June 2010, three Enterobacteriaceae isolates carrying a newly described resistance mechanism, the New Delhi metallo-beta-lactamase (NDM-1), were identified from three U.S. states at the CDC antimicrobial susceptibility laboratory. This is the first report of NDM-1 in the United States, and the first report of metallo-beta-lactamase carriage among Enterobacteriaceae in the United States. These isolates, which include an Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae, carry blaNDM-1, which confers resistance to all beta-lactam agents except aztreonam (a monobactam antimicrobial); all three isolates were aztreonam resistant, presumably by a different mechanism. In the United Kingdom, where these organisms are increasingly common, carriage of Enterobacteriaceae containing blaNDM-1 has been closely linked to receipt of medical care in India and Pakistan. All three U.S. isolates were from patients who received recent medical care in India. |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: MMWR. Morbidity and mortality weekly report Volume: 59 ISSN: 1545-861X ISO Abbreviation: MMWR Morb. Mortal. Wkly. Rep. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-25 Completed Date: 2010-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802429 Medline TA: MMWR Morb Mortal Wkly Rep Country: United States |
Other Details:
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Languages: eng Pagination: 750 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carbapenems / pharmacology Drug Resistance, Bacterial Enterobacter cloacae / drug effects, enzymology*, isolation & purification Escherichia coli / drug effects, enzymology*, isolation & purification Humans India Klebsiella pneumoniae / drug effects, enzymology*, isolation & purification United States beta-Lactamases / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Carbapenems; EC 3.5.2.6/beta-Lactamases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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