Document Detail

Detection of early zone 3 liver fibrosis in chronic alcoholics. A comparison of four connective tissue staining methods.
MedLine Citation:
PMID:  2435106     Owner:  NLM     Status:  MEDLINE    
Fibrous deposits in the perisinusoidal space in the acinar zone 3 are early and prognostically important features of the alcoholic liver lesion. Four connective tissue staining methods: van Gieson's Picro-Fuchsin (VG), Gordon & Sweets' reticulin (GS), Chromotrope Aniline Blue (CAB), and Picro-Sirius (PS) were evaluated concerning their relative sensitivity in the detection of early zone 3 fibrosis. A selected area in 60 liver biopsies with preserved architecture, obtained from chronic alcoholics, were studied. A semiquantitative registration of the degree of fibrosis was made. A comparison between the scores of the various staining methods by means of Pratt's test revealed PS to be significantly the most sensitive method. GS was insignificantly more sensitive than CAB while VG (which in contrast to the other three methods leaves reticulin unstained) was the least sensitive. In five biopsies which only revealed fibrosis in PS, perisinusoidal collagenization was confirmed by transmission electron microscopy. In the histological detection of early zone 3 fibrosis, PS is therefore recommended.
M Vyberg; J Junge; T Horn
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology     Volume:  95     ISSN:  0108-0164     ISO Abbreviation:  Acta Pathol Microbiol Immunol Scand A     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-06     Completed Date:  1987-04-06     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  8206622     Medline TA:  Acta Pathol Microbiol Immunol Scand A     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
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MeSH Terms
Alcoholism / complications*,  pathology
Connective Tissue / metabolism*,  ultrastructure
Evaluation Studies as Topic
Liver Cirrhosis / diagnosis*,  etiology,  metabolism
Microscopy, Electron
Reference Values
Staining and Labeling / methods*,  standards
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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