Document Detail

Detection of early pregnancy factor in fetal sera.
MedLine Citation:
PMID:  2257053     Owner:  NLM     Status:  MEDLINE    
Utilizing rosette inhibition test recommended by Morton et al., (Morton H, Tinneberg HR, Rolfe M, Mettier L. Rosette inhibition test: a multicenter investigation of early pregnancy factor in humans, J Reprod Immunol. 1982; 4:251-261) we have examined 44 fetal sera of abortion induced by water bag in the second and third trimester pregnancy, 4 umbilical sera of newborns, and their 48 maternal sera for detecting early pregnancy factor (EPF), which activity was expressed as rosette inhibition titre (RIT). The mean RIT value of EPF in fetal sera was 6.00 +/- 0.31 (SD) during 16-17 weeks of gestation, gradually decreased along with gestational weeks, got to 4.25 +/- 0.25 by term. The mean RITs of EPF activity in maternal sera were 5.86 +/- 0.26 and 5.89 +/- 0.35 during 5-7 weeks and 18-19 weeks, respectively, decreased afterwards, and then fell into nonpregnant range (RIT: 4.00 +/- 0.40) after 31 weeks of gestation. There was a close correlation between RITs of 44 fetal and those of their maternal sera (r = 0.615; P less than 0.001). The results revealed the presence of EPF in fetal serum during gestation. The significance of EPF distribution and its possible role of immunological regulation on survival of semiallogeneic conceptus have thus been discussed.
H N Wang; Z Q Zheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  23     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Research Laboratory of Reproductive Immunology, Shanxi Medical College, Taiyuan, People's Republic of China.
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MeSH Terms
Amniotic Fluid / chemistry
Chaperonin 10
Fetal Blood / chemistry*
Immunosuppressive Agents / analysis*
Peptides / analysis*
Pregnancy / blood
Pregnancy Proteins*
Rosette Formation
Suppressor Factors, Immunologic*
Reg. No./Substance:
0/Chaperonin 10; 0/Immunosuppressive Agents; 0/Peptides; 0/Pregnancy Proteins; 0/Suppressor Factors, Immunologic; 0/early pregnancy factor

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