| Detection of disordered regions in globular proteins using (13) C-Detected NMR. | |
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MedLine Citation:
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PMID: 23047544 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Characterization of disordered regions in globular proteins constitutes a significant challenge. Here, we report an approach based on (13) C-detected NMR experiments for the identification and assignment of disordered regions in large proteins. Using this method we demonstrate that disordered fragments can be accurately identified in two homologs of menin, a globular protein with a molecular weight over 50kDa. Our work provides an efficient way to characterize disordered fragments in globular proteins for structural biology applications. |
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Authors:
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Felicia L V Gray; Marcelo J Murai; Jolanta Grembecka; Tomasz Cierpicki |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-9 |
Journal Detail:
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Title: Protein science : a publication of the Protein Society Volume: - ISSN: 1469-896X ISO Abbreviation: Protein Sci. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211750 Medline TA: Protein Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 The Protein Society. |
Affiliation:
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Department of Pathology, University of Michigan, 1150 W. Medical Center Drive, MSRB1 4516, Ann Arbor, MI 48109; Program in Chemical Biology, University of Michigan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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