Document Detail


Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation.
MedLine Citation:
PMID:  23149750     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Alterations in the methylation of promoters of cancer-related genes are promising biomarkers for the early detection of disease. Compared with single methylation alteration, assessing combined methylation alterations can provide higher association with specific cancer. Here we use cationic conjugated polymer-based fluorescence resonance energy transfer to quantitatively analyse DNA methylation levels of seven colon cancer-related genes in a Chinese population. Through a stepwise discriminant analysis and cumulative detection of methylation alterations, we acquire high accuracy and sensitivity for colon cancer detection (86.3 and 86.7%) and for differential diagnosis (97.5 and 94%). Moreover, we identify a correlation between the CpG island methylator phenotype and clinically important parameters in patients with colon cancer. The cumulative analysis of promoter methylation alterations by the cationic conjugated polymer-based fluorescence resonance energy transfer may be useful for the screening and differential diagnosis of patients with colon cancer, and for performing clinical correlation analyses.
Authors:
Qiong Yang; Ying Dong; Wei Wu; Chunlei Zhu; Hui Chong; Jiangyang Lu; Dehai Yu; Libing Liu; Fengting Lv; Shu Wang
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Nature communications     Volume:  3     ISSN:  2041-1723     ISO Abbreviation:  Nat Commun     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528555     Medline TA:  Nat Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1206     Citation Subset:  -    
Affiliation:
1] Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China [2].
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