Document Detail

Detection of cytomegalovirus, parvovirus B19 and herpes simplex viruses in cases of intrauterine fetal death: association with pathological findings.
MedLine Citation:
PMID:  18712818     Owner:  NLM     Status:  MEDLINE    
There are previous indications that transplacental transmission of cytomegalovirus (CMV), parvovirus B19 (PB19) and herpes simplex virus types 1 and 2 (HSV-1/2) cause fetal infections, which may lead to fetal death. In a prospective case-control study we examined the incidence of these viruses in intrauterine fetal death and their association with fetal and placenta pathological findings. Molecular assays were performed on placenta tissue extracts of 62 fetal deaths and 35 controls for the detection of CMV, PB19 and HSV-1/2 genomes. Formalin-fixed, paraffin-embedded liver, spleen and placenta tissues of fetal death cases were evaluated histologically. Thirty-four percent of placental specimens taken from intrauterine fetal deaths were positive for any of the three viruses (16%, 13%, and 5% positive for CMV, PB19, and HSV-1/2, respectively), whereas only 6% of those taken from full term newborns were positive (P = 0.0017). No dual infection was observed. This difference was also observed when fetal deaths with a gestational age <20 weeks or a gestational age >20 weeks were compared with the controls (P = 0.025 and P = 0.0012, respectively). Intrauterine death and the control groups differed in the detection rate of CMV DNA (16% and 3%, respectively; P = 0.047), which was more pronounced in a gestational age >20 weeks (P = 0.03). Examination of the pathological findings among the PCR-positive and PCR-negative fetal deaths revealed that hydrops fetalis and chronic villitis were more common among the former group (P = 0.0003 and P = 0.0005, respectively). In conclusion, an association was detected between viral infection and fetal death, which was more pronounced in the advanced gestational age. Fetal hydrops and chronic villitis were evidently associated with viral DNA detection in cases of intrauterine death.
Garyfallia Syridou; Nicholas Spanakis; Anastasia Konstantinidou; Evangelia-Theophano Piperaki; Dimitrios Kafetzis; Efstratios Patsouris; Aris Antsaklis; Athanassios Tsakris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  80     ISSN:  1096-9071     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-10-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1776-82     Citation Subset:  IM    
Department of Microbiology, Medical School, University of Athens, Athens, Greece.
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MeSH Terms
Case-Control Studies
Chorionic Villi / pathology,  virology*
Cytomegalovirus / genetics,  isolation & purification*
Cytomegalovirus Infections / complications,  pathology,  transmission
DNA, Viral / analysis
Fetal Death / etiology,  pathology,  virology*
Fetus / pathology,  virology
Genome, Viral
Gestational Age
Herpes Simplex / complications,  pathology,  transmission
Hydrops Fetalis / etiology,  pathology,  virology*
Infant, Newborn
Infant, Premature
Infectious Disease Transmission, Vertical
Parvoviridae Infections / complications,  pathology,  transmission
Parvovirus B19, Human / genetics,  isolation & purification*
Pregnancy Complications, Infectious / pathology,  virology*
Prospective Studies
Simplexvirus / genetics,  isolation & purification*
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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