Document Detail


Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous system.
MedLine Citation:
PMID:  15609232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The study sought to determine the relationship between cytomegalovirus (CMV) viremia during early infancy and clinical and laboratory outcome events, particularly hearing loss in infants with symptomatic congenital CMV infection involving the central nervous system (CNS). STUDY DESIGN: A total of 147 infant patients were enrolled prospectively in 2 clinical trials evaluating ganciclovir for the treatment of symptomatic congenital CMV infection involving the CNS. Aliquots of serum collected at enrollment in either of the 2 trials were available from 50 of the infants, and the degree of viremia was determined by real-time quantitative polymerase chain reaction. RESULTS: Of the 50 infants from whom serum samples were available, 37 had detectable CMV DNA in the serum sample collected at enrollment and were classified as viremic. Viremic infants were more likely to have (1) hearing loss both at enrollment (P = .045) and at the 6-month follow-up testing (P = .035) and (2) other indicators of active CMV disease, including elevated levels of alanine aminotransferase, petechial rash, and organomegaly. CONCLUSION: In children with symptomatic congenital CMV infection involving the CNS, viremia during early infancy is associated with hearing loss and systemic CMV disease.
Authors:
Russell D Bradford; Gretchen Cloud; Alfred D Lakeman; Suresh Boppana; David W Kimberlin; Richard Jacobs; Gail Demmler; Pablo Sanchez; William Britt; Seng-jaw Soong; Richard J Whitley;
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-12-16
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  191     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-20     Completed Date:  2005-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
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MeSH Terms
Descriptor/Qualifier:
Central Nervous System Diseases / virology*
Cytomegalovirus / genetics,  isolation & purification*
Cytomegalovirus Infections / complications,  congenital*
DNA, Viral / blood*,  isolation & purification
Ganciclovir / administration & dosage,  adverse effects,  therapeutic use
Hearing Loss / epidemiology,  etiology,  virology*
Humans
Infant
Infant, Newborn
Polymerase Chain Reaction
Grant Support
ID/Acronym/Agency:
M01-RR00032/RR/NCRR NIH HHS; N01-AI-15113/AI/NIAID NIH HHS; N01-AI-30025/AI/NIAID NIH HHS; N01-AI-62554/AI/NIAID NIH HHS; N01-AI-65306/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral; 82410-32-0/Ganciclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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