Document Detail


Detection of creatine kinase BB isoenzyme in sera of patients undergoing aortocoronary bypass surgery.
MedLine Citation:
PMID:  300659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Creatine kinase BB isoenzyme (CK-BB) was detected intraoperatively in 22 of 25 patients undergoing aortocoronary bypass surgery, both in the coronary sinus and in the mixed venous blood. In a group of 10 patients in whom selective intracavitary profound hypothermic arrest was used, CK-BB values were lower than in another group of 10 patients, in whom controlled ventricular fibrillation with moderate total body hypothermia was instituted. This latter group also had higher levels of CK-MB. Patients who developed acute myocardial infarction immediately prior to or during the surgical intervention had the highest CK-BB values. This enzyme appeared as early as 15 minutes after the institution of cardiopulmonary bypass and disappeared within 6 hours. It is considered that part of the BB isoenzyme in serum of patients undergoing heart surgery is of myocardial origin.
Authors:
A O Vladutiu; A Schachner; P A Schaefer; G Schimert; T Z Lajos; A B Lee; J H Siegel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  75     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  467-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Coronary Artery Bypass*
Creatine Kinase / blood*,  metabolism
Female
Humans
Isoenzymes / blood*,  metabolism
Male
Middle Aged
Myocardial Infarction / enzymology
Myocardium / enzymology
Rats
Uterus / enzymology
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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