| Detection of cotinine in neonate meconium as a marker for nicotine exposure in utero. | |
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MedLine Citation:
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PMID: 16201714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonate meconium cotinine level was evaluated as a marker of prenatal exposure to nicotine from tobacco smoking by mothers. Mothers admitted to a maternity hospital in Alexandria, Egypt, were divided into 3 groups: 10 active smokers, 10 passive smokers and 10 with no tobacco exposure during pregnancy. Urine and saliva samples were collected from mothers and first-day meconium samples from their neonates. Mean maternal urinary cotinine levels, measured using radioimmunoassay, differed significantly between the 3 groups, as did mean salivary cotinine and mean cotinine levels in meconium. There was a significant positive correlation between cotinine levels in meconium and both maternal urinary and salivary cotinine levels. Meconium is an ideal biological marker for testing direct fetal exposure to tobacco smoke in the neonatal period. |
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Authors:
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N A Sherif; S M Kamel; O S Al-Ashkar; O A Sharaki; E A Seif; E A Hegazy |
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Publication Detail:
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Type: Journal Article; Validation Studies |
Journal Detail:
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Title: Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ Volume: 10 ISSN: 1020-3397 ISO Abbreviation: East. Mediterr. Health J. Publication Date: 2004 Jan-Mar |
Date Detail:
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Created Date: 2005-10-05 Completed Date: 2005-11-08 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9608387 Medline TA: East Mediterr Health J Country: Egypt |
Other Details:
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Languages: eng Pagination: 96-105 Citation Subset: IM |
Affiliation:
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Department of Forensic Medicine and Toxicology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Biological Markers / analysis, metabolism Birth Weight Case-Control Studies Cotinine / analysis*, urine Egypt Female Fetal Hypoxia / etiology Hospitals, University Humans Infant, Newborn Maternal-Fetal Exchange* Meconium / chemistry* Pregnancy Pregnancy Complications / diagnosis*, metabolism Questionnaires Radioimmunoassay Saliva / chemistry Smoking* / adverse effects, metabolism Tobacco Smoke Pollution* / adverse effects, analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Tobacco Smoke Pollution; 486-56-6/Cotinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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