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Detection of circulating tumor cells in peripheral blood of colorectal cancer patients without distant organ metastases.
MedLine Citation:
PMID:  23150200     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: Recently, the detection of circulating tumor cells (CTCs) in peripheral blood has become an important tool for the non-invasive assessment of micrometastases and to predict clinical outcome. The objective of this study was to investigate if the presence of CTCs in peripheral blood influences the prognosis in colorectal cancer (CRC) patients without distant organ metastases. METHODS: The GCC mRNA and CK20 mRNA levels in peripheral blood and the serum levels of CEA of 92 CRC patients without distant organ metastasis were analyzed by quantitative RT-PCR and ELISA, respectively. Its associations with overall survival (OS) and disease-free survival (DFS) rates were analyzed. RESULTS: Univariate analyses showed that lower OS and DFS rates were significantly associated with GCC and CK20 mRNA levels, the presence of lymph node metastases, the presence of mesenteric root lymph node metastases, and the presence of tumor emboli in vessels (p < 0.05), but not with CEA levels. Multivariate analyses showed a significant association between 1) OS and GCC mRNA levels and differentiation types and 2) DFS and the presence of tumor emboli in the vessels. Kaplan-Meier curves showed that DFS was significantly associated with the presence of poorly differentiated cells, the presence of mesenteric root lymph node metastases having received prior chemotherapy, and the presence of tumor emboli in vessels. CONCLUSION: The detection of CTCs in peripheral blood may be useful for the prediction of clinical outcome in CRC patients without distant organ metastases.
Authors:
Yong Liu; Jun Qian; Jian-Guo Feng; Hai-Xing Ju; Yu-Ping Zhu; Hai-Yang Feng; De-Chuan Li
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Cellular oncology (Dordrecht)     Volume:  -     ISSN:  2211-3436     ISO Abbreviation:  Cell Oncol (Dordr)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101552938     Medline TA:  Cell Oncol (Dordr)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Surgical Department of Colorectal Cancer, Zhejiang Cancer Hospital, Guangji road, No 38, Banshan Bridge, Gongshu District, Hangzhou, 310022, Zhejiang Province, China.
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