| Detection of circulating superantigens in an intensive care unit population. | |
| | |
MedLine Citation:
|
PMID: 15325598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Plasma concentrations of superantigens were measured in an intensive care unit (ICU) population and the relationship of superantigen positive rates with the presence of sepsis was investigated. METHODS: Plasma samples were collected at least twice a week from 78 patients whose primary diagnoses were abdominal disorders (n = 27), respiratory disorders (n = 11), trauma (n = 10), burns (n = 10), cardiovascular disorders (n = 4), neurological disorders (n = 2), and others (n = 14). Five different species of superantigens, i.e., staphylococcal enterotoxins A, B, and C (SEA, SEB, and SEC), toxic shock syndrome toxin-1 (TSST-1), and streptococcal pyrogenic exotoxin A (SPEA), were measured using an enzyme-linked immunosorbent assay. RESULTS: Significant levels of plasma superantigens were detected in 16 patients. SEA was found in seven patients, SEB in four patients, SEC in two patients, TSST-1 in six patients, and SPEA in five patients. Superantigen detection rates were 6% (1/17) in patients without systemic inflammatory response syndrome (SIRS), 0% (0/21) in SIRS patients without infection, 31% (5/16) in septic patients without shock, and 42% (10/24) in septic shock patients. CONCLUSIONS: The presence of superantigens was confirmed in part of the ICU population. The role of superantigens in the pathogenesis of sepsis remains to be determined. |
| | |
Authors:
|
Kazuaki Azuma; Kaoru Koike; Tatsuho Kobayashi; Toru Mochizuki; Kunihiro Mashiko; Yasuhiro Yamamoto |
Related Documents
:
|
660698 - The use of microscopy as a guide to primary excision of high-tension electrical burns. 21355418 - Determination of oxidant stress in plasma of rheumatoid arthritis and primary osteoarth... 2031818 - Effect of inspired oxygen concentration on the incidence of desaturation in patients un... 21112918 - Imbalance in the stress-adaptation system in patients with inflammatory bowel disease. 11057798 - Cervical spine clearance and neck extension during percutaneous tracheostomy in trauma ... 20105278 - Effect of proximal gastric volume on hiatal hernia. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases Volume: 8 ISSN: 1201-9712 ISO Abbreviation: Int. J. Infect. Dis. Publication Date: 2004 Sep |
Date Detail:
|
Created Date: 2004-08-24 Completed Date: 2004-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9610933 Medline TA: Int J Infect Dis Country: Canada |
Other Details:
|
Languages: eng Pagination: 292-8 Citation Subset: IM |
Affiliation:
|
Department of Emergency and Critical Care Medicine, Chiba-Hokuso Hospital, Nippon Medical School, Chiba, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Bacterial Proteins / blood* Bacterial Toxins / blood* Enterotoxins / blood* Enzyme-Linked Immunosorbent Assay Exotoxins / blood* Female Humans Intensive Care Units* Male Membrane Proteins / blood* Middle Aged Sepsis / blood, epidemiology* Shock, Septic / blood Staphylococcus aureus / metabolism* Superantigens / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Bacterial Proteins; 0/Bacterial Toxins; 0/Enterotoxins; 0/Exotoxins; 0/Membrane Proteins; 0/SpeA protein, Streptococcus pyogenes; 0/Superantigens; 0/enterotoxin F, Staphylococcal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Resistance trends of Acinetobacter spp. in Latin America and characterization of international disse...
Next Document: Crimean-Congo hemorrhagic fever in Sistan and Baluchestan Province of Iran, a case-control study on ...