Document Detail

Detection of circulating superantigens in an intensive care unit population.
MedLine Citation:
PMID:  15325598     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Plasma concentrations of superantigens were measured in an intensive care unit (ICU) population and the relationship of superantigen positive rates with the presence of sepsis was investigated. METHODS: Plasma samples were collected at least twice a week from 78 patients whose primary diagnoses were abdominal disorders (n = 27), respiratory disorders (n = 11), trauma (n = 10), burns (n = 10), cardiovascular disorders (n = 4), neurological disorders (n = 2), and others (n = 14). Five different species of superantigens, i.e., staphylococcal enterotoxins A, B, and C (SEA, SEB, and SEC), toxic shock syndrome toxin-1 (TSST-1), and streptococcal pyrogenic exotoxin A (SPEA), were measured using an enzyme-linked immunosorbent assay. RESULTS: Significant levels of plasma superantigens were detected in 16 patients. SEA was found in seven patients, SEB in four patients, SEC in two patients, TSST-1 in six patients, and SPEA in five patients. Superantigen detection rates were 6% (1/17) in patients without systemic inflammatory response syndrome (SIRS), 0% (0/21) in SIRS patients without infection, 31% (5/16) in septic patients without shock, and 42% (10/24) in septic shock patients. CONCLUSIONS: The presence of superantigens was confirmed in part of the ICU population. The role of superantigens in the pathogenesis of sepsis remains to be determined.
Kazuaki Azuma; Kaoru Koike; Tatsuho Kobayashi; Toru Mochizuki; Kunihiro Mashiko; Yasuhiro Yamamoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  8     ISSN:  1201-9712     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-24     Completed Date:  2004-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  292-8     Citation Subset:  IM    
Department of Emergency and Critical Care Medicine, Chiba-Hokuso Hospital, Nippon Medical School, Chiba, Japan.
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MeSH Terms
Aged, 80 and over
Bacterial Proteins / blood*
Bacterial Toxins / blood*
Enterotoxins / blood*
Enzyme-Linked Immunosorbent Assay
Exotoxins / blood*
Intensive Care Units*
Membrane Proteins / blood*
Middle Aged
Sepsis / blood,  epidemiology*
Shock, Septic / blood
Staphylococcus aureus / metabolism*
Superantigens / blood*
Reg. No./Substance:
0/Bacterial Proteins; 0/Bacterial Toxins; 0/Enterotoxins; 0/Exotoxins; 0/Membrane Proteins; 0/SpeA protein, Streptococcus pyogenes; 0/Superantigens; 0/enterotoxin F, Staphylococcal

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