| Detection of circulating fetal nucleic acids: a review of methods and applications. | |
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MedLine Citation:
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PMID: 19329710 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The discovery of cell-free circulating fetal nucleic acids in maternal plasma has opened up new possibilities in non-invasive prenatal diagnosis. The rapid advancement of this field in the past decade is catalysed by the discovery of new classes of fetal nucleic acid markers and technological developments in nucleic acid detection and amplification. In this review, some of the more significant recent developments in this field will be discussed, including the detection of single molecule, chromosomal aneuploidies, single nucleotide variations and placental microRNAs in maternal plasma. |
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Authors:
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E C W Hung; R W K Chiu; Y M D Lo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of clinical pathology Volume: 62 ISSN: 1472-4146 ISO Abbreviation: J. Clin. Pathol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: England |
Other Details:
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Languages: eng Pagination: 308-13 Citation Subset: AIM; IM |
Affiliation:
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Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, and Department of Chemical Pathology, The Chinese University of Hong Kong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy Biological Markers / blood Female Fetal Diseases / diagnosis* Humans MicroRNAs / blood Nucleic Acids / blood* Polymorphism, Single Nucleotide Pregnancy Prenatal Diagnosis / methods* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/MicroRNAs; 0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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