| Detection of chronic lymphocytic leukemia cell surface markers using surface enhanced Raman scattering gold nanoparticles. | |
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MedLine Citation:
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PMID: 20042272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Selective targeting and detection of a hematologic malignancy, chronic lymphocytic leukemia, using surface enhanced Raman scattering (SERS) gold nanoparticles is reported. The functional nanoparticles were composed of a gold core onto which an optical reporter dye was adsorbed, protected from aggregation by grafted polyethyleneglycol, and targeted to CD19 antigen by antibodies. The signals were detected by dark-field microscopy and Raman spectrometry. The observation that the Raman signals are not disrupted by several traditional pathology stains indicates advantages over fluorescence methods. |
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Authors:
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Collin T Nguyen; James T Nguyen; Steven Rutledge; Janing Zhang; Chen Wang; Gilbert C Walker |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-29 |
Journal Detail:
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Title: Cancer letters Volume: 292 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-13 Completed Date: 2010-04-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Chemistry, University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD19
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analysis* Gold* Humans Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis* Metal Nanoparticles / chemistry Nanoparticles* Nanotechnology Spectrum Analysis, Raman / methods* |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD19; 7440-57-5/Gold |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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