Document Detail

Detection of the t(2;5)(p23;q35) chromosomal translocation in large B-cell lymphomas other than anaplastic large cell lymphoma.
MedLine Citation:
PMID:  8666370     Owner:  NLM     Status:  MEDLINE    
In general, the large cell lymphomas are a cytogenetically heterogeneous group of diseases, and the cytogenetic findings do not correlate with morphological findings in this group of malignant lymphomas. The CD30-positive anaplastic large cell lymphomas, however, are thought to be an exception, with the t(2;5) reported to correlate with the morphological changes of this disease entity. A subgroup of Hodgkin's disease cases have been reported by some investigators to have the t(2;5) translocation, leading to speculation that these two diseases are related. In the current study, the authors used a sensitive reverse transcriptase polymerase chain reaction (RT-PCR) methodology to evaluate the frequency of t(2;5) in 33 cases of large cell lymphoma, of B lineage, other than anaplastic large cell lymphoma. The authors detected evidence of t(2;5) in four of the cases (12%), a frequency similar to that of the authors' previous study of cases of CD30 positive anaplastic large cell lymphoma. Three of the positive large B-cell lymphoma cases were CD30 negative and were morphologically indistinguishable from the cases without evidence of t(2;5). The fourth case had a subpopulation of CD30 positive cells but also did not have morphological features of anaplastic large cell lymphoma. These results would suggest that t(2;5) is not restricted to cases of malignant lymphomas with anaplastic morphology or to CD30 expression.
D A Arber; L H Sun; L M Weiss
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  27     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-05     Completed Date:  1996-08-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  590-4     Citation Subset:  IM    
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
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MeSH Terms
Aged, 80 and over
Base Sequence
Chromosomes, Human, Pair 2 / genetics*
Chromosomes, Human, Pair 5 / genetics*
Lymphoma, B-Cell / genetics*,  pathology*
Lymphoma, Large B-Cell, Diffuse / genetics*,  pathology*
Lymphoma, Large-Cell, Immunoblastic / genetics,  pathology
Middle Aged
Molecular Sequence Data
Translocation, Genetic*

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