Document Detail

Detection of cholangiocarcinoma in vivo using miniprobe-based confocal fluorescence microscopy.
MedLine Citation:
PMID:  18639496     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: The preoperative diagnosis of cholangiocarcinoma is associated with a low sensitivity. To overcome this limitation, a new imaging modality was evaluated to detect neoplasia in vivo in the biliary tract. METHODS: Fourteen patients with biliary strictures were examined. Mucosal imaging was performed with a miniaturized confocal laser scanning miniprobe introduced via the accessory channel of a cholangioscope. Thereafter, targeted biopsy specimens were taken from the same regions. RESULTS: All strictures could be reached. Presence of irregular vessels use confocal laser microscopy enabled prediction of neoplasia with an accuracy rate of 86%, sensitivity of 83%, and specificity of 88%. The respective numbers for standard histopathology were 79%, 50%, and 100%. The mean signal-to-noise-ratio of laser microscopic images acquired from malignant strictures differed significantly from those of benign origin (1.8 +/- 0.8 vs 2.6 +/- 1.0; P = .005). CONCLUSIONS: Miniprobe-based confocal laser scanning microscopy considerably increases sensitivity for the detection of biliary neoplasia and therefore represents a promising diagnostic approach.
Alexander Meining; Eckart Frimberger; Valentin Becker; Stefan Von Delius; Claus Hann Von Weyhern; Roland M Schmid; Christian Prinz
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-17
Journal Detail:
Title:  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association     Volume:  6     ISSN:  1542-7714     ISO Abbreviation:  Clin. Gastroenterol. Hepatol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160775     Medline TA:  Clin Gastroenterol Hepatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1057-60     Citation Subset:  IM    
Department of Medicine II, Technical University of Munich, Munich, Germany.
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MeSH Terms
Cholangiocarcinoma / diagnosis*
Cholangiopancreatography, Endoscopic Retrograde / methods*
Intestinal Mucosa / pathology
Microscopy, Confocal / methods*
Middle Aged
Sensitivity and Specificity

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