| Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents. | |
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MedLine Citation:
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PMID: 19208518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gadolinium-enhanced multi-phase dynamic imaging has improved the accuracy of the diagnosis of hypervascular hepatocellular carcinoma (HCC), but using gadolinium-enhanced dynamic imaging alone is problematic in evaluating hypovascular HCC. This work aimed at evaluating the combined use of superparamagnetic iron oxide (SPIO)-enhanced and gadolinium set in distinguishing HCCs from regenerative nodules (RNs) in a rat model induced by diethylnitrosamine (DEN). METHODS: DEN-induced HCC model rats (n=40) and control rats (n=10) were studied. From weeks 16 to 19 after DEN administration, 4 animals were scanned every week. The hepatic changes were tested with a 1.5 Tesla magnet, and MR images of SPIO-enhanced and gadolinium set were obtained. According to the pathologic changes, the tumorigenesis was divided into HCC and RN (diameter of nodules > or =3 mm). Diagnostic accuracy of the combined SPIO-enhanced and gadolinium set and the gadolinium set alone was evaluated using receiver-operating characteristic curves. Sensitivity and specificity of the combined SPIO-enhanced and gadolinium set and the gadolinium set alone were calculated. RESULTS: The listed tests were completed in 29 rats (21 treated and 8 controls). One hundred and six nodules (82 HCCs, 24 RNs) were analyzed. The Az value and sensitivity with the combined SPIO-enhanced and gadolinium set (Az 0.94, sensitivity 0.96) were higher than those with the gadolinium set alone (Az 0.92, sensitivity 0.89). Using the combined SPIO-enhanced and gadolinium set led to detection of 6 nodules which were negative in the gadolinium set alone and 3 nodules were correctly characterized. CONCLUSION: Using the combined SPIO-enhanced and gadolinium set improved the detectability of HCCs and the SPIO-enhanced imaging compensated for the gadolinium set in differentiating HCCs from RNs in a rat model. |
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Authors:
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Dong-Mei Guo; Tian-Shuang Qiu; Jie Bian; Shu-Feng Liu; Chang-Zheng Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hepatobiliary & pancreatic diseases international : HBPD INT Volume: 8 ISSN: 1499-3872 ISO Abbreviation: HBPD INT Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-11 Completed Date: 2009-05-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101151457 Medline TA: Hepatobiliary Pancreat Dis Int Country: China |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: IM |
Affiliation:
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Department of Electronic Engineering, Dalian University of Technology, Dalian 116024, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkylating Agents Animals Carcinoma, Hepatocellular / complications, pathology* Contrast Media / diagnostic use* Diethylnitrosamine Disease Models, Animal False Negative Reactions False Positive Reactions Ferric Compounds / diagnostic use Gadolinium / diagnostic use Liver Cirrhosis / chemically induced, etiology, pathology* Liver Neoplasms, Experimental / complications, pathology* Magnetic Resonance Imaging / methods*, standards Male Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Alkylating Agents; 0/Contrast Media; 0/Ferric Compounds; 1309-37-1/ferric oxide; 55-18-5/Diethylnitrosamine; 7440-54-2/Gadolinium |
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