Document Detail

Detection and care of women with gestational diabetes mellitus from early weeks of pregnancy results in birth weight of newborn babies appropriate for gestational age.
MedLine Citation:
PMID:  18249458     Owner:  NLM     Status:  MEDLINE    
The policy of screening for gestational diabetes mellitus (GDM) between 24 and 28 weeks of gestation and care has resulted in a few women delivering big babies despite good glycemic control. Hence we undertook a study to assess the merits of care given to women in whom GDM was diagnosed in different weeks of gestation and to find out the ideal period of screening in women with history of high-risk pregnancies. A total of 207 consecutive pregnant women irrespective of trimester referred to our referral clinic for diabetes in pregnancy, underwent a 75g oral glucose tolerance test (OGTT) and GDM was diagnosed if 2h plasma glucose (PG) >/=140mg/dl. A1c was estimated in all of them. Women who failed to respond to medical nutrition therapy were advised insulin and the dose titrated to maintain fasting PG (FPG) <90mg/dl and 2h PG <120mg/dl. The mean age of the population screened was 28.38+/-4.31 years and the mean gestational age of screening was 20.05+/-10.71 weeks. Among them, 87 were diagnosed as GDM. The gestational week at diagnosis was </=12 in 36 (41.4%) women (group 1), between 13 and 23 in 18 (20.7%) (group 2), between 24 and 30 in 15 (17.2%) (group 3) and beyond 30 weeks of gestation in 18 (20.7%) (group 4). The A1c was 5.34+/-0.43% in normal glucose tolerance (NGT) women, while it was 6.93+/-1.62% in group 1, 6.03 +/-0.79% in group 2, 6.14+/-0.93% in group 3 and 6.20+/-0.31% in group 4, respectively. The birth weight of babies born to women with NGT was 3.28+/-0.50kg. The birth weight of babies born to GDM women in group 1, group 2, group 3 and group 4 was 3.15+/-0.48, 3.09+/-0.68, 3.32+/-0.51 and 3.51+/-0.63kg, respectively. Group 1 women in spite of the history of high-risk pregnancies, delivered babies appropriate for gestational age like NGT women. Screening in the first trimester of pregnancy and institution of therapy is advisable in women with high-risk pregnancies.
V Seshiah; Alexander Cynthia; V Balaji; Madhuri S Balaji; S Ashalata; Rajan Sheela; M Thamizharasi; T Arthi
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Publication Detail:
Type:  Journal Article     Date:  2008-02-04
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  80     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  199-202     Citation Subset:  IM    
Dr. V. Seshiah Diabetes Care and Research Institute, 31A, Ormes Road, Kilpauk, Chennai 600010, Tamilnadu, India.
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MeSH Terms
Birth Weight*
Blood Glucose / metabolism
Diabetes, Gestational / diagnosis,  physiopathology*
Diagnosis, Differential
Gestational Age*
Glucose Tolerance Test
Infant, Newborn
Medical History Taking
Reference Values
Reg. No./Substance:
0/Blood Glucose

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