Document Detail


Detection of the cardiovascular complications of thalassemia by echocardiography.
MedLine Citation:
PMID:  20712789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The thalassemia syndromes are associated with cardiovascular complications, which differ with the varying phenotypes encountered. The well-recognized paradigm of heart failure induced by myocardial iron overload, in thalassemia major (TM), has now been joined by pulmonary arterial hypertension (mostly seen in thalassemia intermedia) among other more subtle disorders of the cardiovascular system, including endothelial dysfunction. Cardiovascular magnetic resonance (T2*) has allowed cardiac iron load to be quantified noninvasively, and the routine measurement of T2* has been associated with a marked improvement in the outlook for patients with TM, in particular. Echocardiography remains an indispensable tool in the cardiovascular assessment of patients, it provides many insights into cardiovascular function, and its use allows improved management of patients. It is particularly suited to assess diastolic function, diagnose intracardiac masses (usually thrombus), and assess right ventricular function and pulmonary pressure.
Authors:
John Malcolm Walker; Sunil Nair
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1202     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-17     Completed Date:  2010-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Affiliation:
Hatter Cardiovascular Institute, University College Hospital, London, United Kingdom. malcolm.walker@uclh.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Echocardiography / methods
Echocardiography, Doppler
Heart Diseases / etiology*,  physiopathology*
Humans
Iron / metabolism
Iron Overload / complications*,  etiology,  physiopathology
Thalassemia / complications*,  physiopathology*
Ventricular Function, Left
Chemical
Reg. No./Substance:
7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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