Document Detail


Detection of cardiac variability in the isolated rat heart.
MedLine Citation:
PMID:  16766629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac variability can be assessed from two perspectives: beat-to-beat performance and continuous performance during the cardiac cycle. Linear analysis techniques assess cardiac variability by measuring the physical attributes of a signal, whereas nonlinear techniques evaluate signal dynamics. This study sought to determine if recurrence quantification analysis (RQA), a nonlinear technique, could detect pharmacologically induced autonomic changes in the continuous left ventricular pressure (LVP) and electrographic (EC) signals from an isolated rat heart-a model that theoretically contains no inherent variability. LVP and EC signal data were acquired simultaneously during Langendorff perfusion of isolated rat hearts before and after the addition of acetylcholine (n = 11), norepinephrine (n = 12), or no drug (n = 12). Two-minute segments of the continuous LVP and EC signal data were analyzed by RQA. Findings showed that%recurrence,%determinism, entropy, maxline, and trend from the continuous LVP signal significantly increased in the presence of both acetylcholine and norepinephrine, although systolic LVP significantly increased only with norepinephrine. In the continuous EC signal, the RQA trend variable significantly increased in the presence of norepinephrine. These results suggest that when either the sympathetic or parasympathetic division of the autonomic nervous system overwhelms the other, the dynamics underlying cardiac variability become stationary. This study also shows that information concerning inherent variability in the isolated rat heart can be gained via RQA of the continuous cardiac signal. Although speculative, RQA may be a tool for detecting alterations in cardiac variability and evaluating signal dynamics as a nonlinear indicator of cardiac pathology.
Authors:
Autumn M Schumacher; Joseph P Zbilut; Charles L Webber; Dorie W Schwertz; Mariann R Piano
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Biological research for nursing     Volume:  8     ISSN:  1099-8004     ISO Abbreviation:  Biol Res Nurs     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-08-18     Revised Date:  2006-10-13    
Medline Journal Info:
Nlm Unique ID:  9815758     Medline TA:  Biol Res Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-66     Citation Subset:  IM; N    
Affiliation:
Department of Physiological and Technological Nursing, School of Nursing at the Medical College of Georgia, Augusta, 30912, USA. aschumacher@mcg.edu
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Animals
Atenolol / pharmacology
Atropine / pharmacology
Autonomic Nervous System / drug effects*,  physiology
Cholinergic Agents / pharmacology
Disease Models, Animal
Electrocardiography* / methods
Heart Rate / drug effects*,  physiology
Male
Monitoring, Physiologic
Nonlinear Dynamics*
Norepinephrine / pharmacology
Numerical Analysis, Computer-Assisted*
Parasympatholytics / pharmacology
Phentolamine / pharmacology
Random Allocation
Rats
Rats, Sprague-Dawley
Signal Processing, Computer-Assisted*
Sympatholytics / pharmacology
Sympathomimetics / pharmacology
Systole
Ventricular Pressure / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Cholinergic Agents; 0/Parasympatholytics; 0/Sympatholytics; 0/Sympathomimetics; 29122-68-7/Atenolol; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 51-55-8/Atropine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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