Document Detail


Detection of brain tumors using fluorescence diffuse optical tomography and nanoparticles as contrast agents.
MedLine Citation:
PMID:  23208215     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT. Near-infrared fluorescence-enhanced diffuse optical tomography (fDOT) is used to localize tumors in mice using fluorescent nanoparticles as a blood pool contrast agent. The infrared dye DiR is loaded in the lipid core of nontargeted nanoparticles (DiR-lipidots) and injected systemically via the tail vein in mice bearing U87 tumors. Distribution and time-course of DiR-lipidots are followed using in vivo fluorescence reflectance imaging and reveal enhanced fluorescent signal within the subcutaneous tumors up to seven days due to the enhanced permeability and retention effect. Tumor growth into the brain is followed using bioluminescent imaging, and tumor localization is further determined by magnetic resonance imaging. The fDOT provides three-dimensional fluorescent maps that allow for consistent localization for both subcutaneous and brain tumors.
Authors:
Pierre-Yves Fortin; Coralie Genevois; Anne Koenig; Emilie Heinrich; Isabelle Texier; Franck Couillaud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  17     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  126004     Citation Subset:  IM    
Affiliation:
Université Bordeaux Segalen, Laboratoire IMF, CNRS/UMR 5231, Université Bordeaux 2, FrancebUniversité Bordeaux Segalen, Institut de BioImagerie, CNRS/UMS 3428, Université Bordeaux 2, France.
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