Document Detail


Detection of biomarkers with graphene nanoplatelets and nanoribbons.
MedLine Citation:
PMID:  24400315     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Well-defined graphene nanosheets have become increasingly popular in the electrochemical detection and quantification of small molecules. In this work, the electrochemical oxidation of biomarkers such as uric acid, ascorbic acid, dopamine, NADH and DNA bases, namely guanine and adenine, was performed using cyclic voltammetry and differential pulse voltammetry to compare the electrochemical properties of electrochemically reduced nanoplatelets (ENPs) and electrochemically reduced nanoribbons (ENRs). The graphene materials displayed better electrochemical performances than the bare glassy carbon surface. Between the two graphene materials, the oxidation of biomarkers occurred at lower oxidation potentials on the ENP surface. The sensitivities of the two graphene surfaces varied when different biomarkers were studied. The ENP surface showed enhanced sensitivities for ascorbic acid, while the ENR surface exhibited higher sensitivities for uric acid and dopamine. As for the DNA bases analysed, both guanine and adenine were oxidised at lower potentials on the ENP surface than the ENR surface. The ENP surface displayed a better sensitivity for guanine, whereas the oxidation of adenine was more sensitive on the ENR surface.
Authors:
Chee Shan Lim; Chun Kiang Chua; Martin Pumera
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-7
Journal Detail:
Title:  The Analyst     Volume:  -     ISSN:  1364-5528     ISO Abbreviation:  Analyst     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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