Document Detail

Detection of autoantibodies to ribosome P in lupus patients with neurological involvement.
MedLine Citation:
PMID:  19366083     Owner:  NLM     Status:  MEDLINE    
Autoantibodies to ribosome P react with the cytoplasmic ribosomes and are specific for the diagnostic of lupus with neurological involvement. The objective of this study was to assess prevalence of serum autoantibodies to ribosome P as a biomarker for lupus with neurological involvement. We measured serum autoantibodies in 47 lupus patients with neurological involvement (range 31-52 years, mean age 38.6 years) as compared to 31 patients with lupus without neurological involvement (range 28-56 years, mean age 41.2 years) and 56 healthy subjects matching with both groups with regard to sex and age. Serum autoantibodies to ribosome P were measured by means of ELISA test. The results were statistically analyzed using the Student t-test. A value of p < 0.05 was considered significant. Autoantibodies to ribosome P were detected in 43 (91%) oflupus patients with neurological involvement and in 7 (15%) lupus patients without neurological involvement (p < 0.001). The results confirm that these autoantibodies are released into the blood, they can be easily measured, and they correlate with outcome including neurological involvement. This study provides additional information with regard to autoantibodies to ribosome P in Romanian lupus population with neurological involvement. Detection of autoantibodies to ribosome P appears useful for diagnostic purpose. Higher peak of serum autoantibodies to ribosome P levels correlated well with neurological involvement (highly specific).
Inimioara Mihaela Cojocaru; M Cojocaru; R Tănăsescu; Cecilia Burcin; Adina Nicoleta Atanasiu; Isabela Silosi
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  46     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2008  
Date Detail:
Created Date:  2009-04-15     Completed Date:  2009-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  239-42     Citation Subset:  IM    
"Carol Davila" University of Medicine and Pharmacy, Clinic of Neurology, Colentina Clinical Hospital, Bucharest, Romania.
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MeSH Terms
Autoantibodies / blood*
Biological Markers / blood
Case-Control Studies
Lupus Vasculitis, Central Nervous System / diagnosis,  immunology*
Middle Aged
Ribosomal Proteins / immunology*
Severity of Illness Index
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/Ribosomal Proteins

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