| Detection of antioxidant enzyme activities in renal tissues of early stage IgA nephropathy in ddY mice. | |
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MedLine Citation:
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PMID: 8951608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the antioxidant enzyme activities in renal tissues of early stage ddY mice, an animal model for primary IgA nephropathy. Eight- and 40-week-old ddY female mice and normal healthy Balb/c female mice were used in this study. The levels of Cu/Zn-SOD, Mn-SOD, and GSH-PX activities in the renal cortex were significantly higher in 40-week-old ddY mice than in Balb/c control mice of the same age; no change of catalase activity was observed. There were no significant differences in the levels of Cu/Zn-SOD, Mn-SOD, GSH-PX, and catalase activities between the ddY mice and Balb/c mice at 8 weeks of age. Urinary protein was slightly higher in 40-week-old ddY mice. IgA or C3 was deposited at low levels in the glomerular mesangial areas of 8-week-old ddY mice. Marked depositions of IgA and C3 extended from the glomerular mesangial areas to the capillary walls of 40-week-old ddY mice. Expansion of glomerular mesangial matrices and mild mesangial cell proliferation was observed in 40-week-old ddY mice. Antioxidant enzyme activities in the renal cortex were already increased in the early stage IgA nephropathy in 40-week-old ddY mice. These findings suggest that measurements of antioxidant enzyme activities in the renal cortex of 40-week-old ddY mice was useful for evaluation of the pathogenesis of renal involvement in the early stage of IgA nephropathy. |
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Authors:
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L N Wang; M Fukui; I Shou; Y Yaguchi; K Funabiki; S Horikoshi; I Shirato; Y Tomino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical laboratory analysis Volume: 10 ISSN: 0887-8013 ISO Abbreviation: J. Clin. Lab. Anal. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-03-07 Completed Date: 1997-03-07 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8801384 Medline TA: J Clin Lab Anal Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 394-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Cell Division / genetics Complement C3 / metabolism Female Fluorescent Antibody Technique Glomerular Mesangium / chemistry, metabolism Glomerulonephritis, IGA / metabolism* Glutathione Peroxidase Immunoglobulin A / metabolism Kidney / enzymology, injuries, pathology Mice Mice, Inbred Strains Microscopy, Fluorescence Proteinuria Superoxide Dismutase / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Complement C3; 0/Immunoglobulin A; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
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