| Detection and amplification of a small enantiomeric imbalance in alpha-amino acids by a helical poly(phenylacetylene) with crown ether pendants. | |
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MedLine Citation:
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PMID: 12553829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have designed a novel stereoregular poly(phenylacetylene) bearing the bulky crown ether as the pendant (poly-1) for the amino acid binding site. The polymer forms a one-handed helix upon complexation with l-amino acid perchlorates, and the complexes exhibit an induced circular dichroism (ICD) with the same Cotton effect signs in the polymer backbone region through a significant cooperative interaction. Poly-1 is highly sensitive to the amino acid chirality and can detect an extremely small enantiomeric imbalance in alpha-amino acids (less than 0.005% enantiomeric excess of alanine, for example). |
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Authors:
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Ryuji Nonokawa; Eiji Yashima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 125 ISSN: 0002-7863 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-29 Completed Date: 2003-04-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 1278-83 Citation Subset: IM |
Affiliation:
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Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylene
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analogs & derivatives*,
chemistry* Amino Acids / chemistry* Amino Alcohols / chemistry Circular Dichroism Ethers, Cyclic / chemistry* Models, Molecular Polymers / chemistry Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Amino Alcohols; 0/Ethers, Cyclic; 0/Polymers; 536-74-3/phenylacetylene; 74-86-2/Acetylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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