Document Detail

Detection of the action of salicylic acid on the normal stratum corneum.
MedLine Citation:
PMID:  7426416     Owner:  NLM     Status:  MEDLINE    
The undoubted clinical usefulness of salicylic acid contrasts markedly with its barely detectable action on normal skin. In this study we have attempted to extend our understanding of the action of salicylic acid by monitoring its effect on the stratum corneum using newly developed techniques for assessing desquamation, as well as using conventional methods for measuring other aspects of epidermal activity. Our findings have succeeded in demonstrating that salicylic acid enhances the shedding of corneocytes and we suggest that this compound in some way decreases corneocyte to corneocyte cohesion. We have confirmed that salicylic acid has no effect on the mitotic activity of the normal epidermis.
D L Roberts; R Marshall; R Marks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  103     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-01-16     Completed Date:  1981-01-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  191-6     Citation Subset:  IM    
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MeSH Terms
Cell Count
Dansyl Compounds
Epidermis / cytology,  drug effects*
Ethanol / pharmacology
Middle Aged
Mitosis / drug effects
Salicylic Acids / pharmacology*
Silver Nitrate
Time Factors
Reg. No./Substance:
0/Dansyl Compounds; 0/Salicylic Acids; 64-17-5/Ethanol; 7761-88-8/Silver Nitrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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