| Detection of small hepatocellular carcinoma: intraindividual comparison of gadoxetic acid-enhanced MRI at 3.0 and 1.5 T. | |
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MedLine Citation:
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PMID: 21467946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the diagnostic efficacy of gadoxetic acid-enhanced magnetic resonance imaging (MRI) at 3.0 T for the detection of hepatocellular carcinomas (HCC) and compare with that at 1.5 T. MATERIALS: Forty patients with 54 HCCs (size range: 0.6-2.0 cm) underwent gadoxetic acid-enhanced MRIs at both 1.5 and 3.0 T with 3 to 8 days interval. The MRIs were compared quantitatively by measuring tumor-liver contrast-to-noise ratio, and qualitatively by evaluating tumor-liver contrast using matched pairs analysis. Diagnostic accuracy and sensitivity were also evaluated by the consensus readings of 2 reviewers using the alternative-free response receiver operator characteristic (ROC) method. RESULTS: Although the tumor-liver contrast-to-noise ratio for the arterial phase was significantly higher at 3.0 T than at 1.5 T (30.2 ± 21.4 vs. 35.2 ± 22.9; P = 0.04), we found similar values for the hepatocyte phase (38.2 ± 24.6 vs. 38.4 ± 25.3; P = 0.762). Matched pairs analysis indicated that the relative tumor-liver contrast was better in 7 and 9 lesions in the arterial phase and hepatocyte phase at 3.0 T, respectively, than those at 1.5 T. The diagnostic accuracy and sensitivity of 3.0-T imaging [Az, 0.988; 92.6% (n = 50)] were slightly higher than those of 1.5-T imaging [Az, 0.981; 88.9% (n = 48)], but the difference was not statistically significant (P = 0.487). CONCLUSIONS: Gadoxetic acid-enhanced MRIs at 1.5 and 3.0 T showed similar diagnostic performances for detecting small HCCs. However, there was a tendency toward increased reader confidence for the arterial phase and hepatocyte phase with 3.0 T compared with 1.5 T. |
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Authors:
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Young Kon Kim; Chong Soo Kim; Young Min Han; Hee Chul Yu; Dongil Choi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 46 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-09 Completed Date: 2011-08-24 Revised Date: 2011-09-28 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 383-9 Citation Subset: IM |
Affiliation:
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Sungkyunkwan University School of Medicine. Department of Radiology, Samsung Medical Center,Sungkyunkwan University School of Medicine, Seoul, South Korea. jmyr@dreamwiz.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Hepatocellular / diagnosis*, radiography Contrast Media* Female Gadolinium DTPA* Humans Image Enhancement / methods Liver Neoplasms / diagnosis*, radiography Magnetic Resonance Imaging* Male Middle Aged Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/gadolinium ethoxybenzyl DTPA; 80529-93-7/Gadolinium DTPA |
| Comments/Corrections | |
Erratum In:
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Invest Radiol. 2011 Sep;46(9):600 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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