Document Detail


Detection of QTL controlling metabolism, meat and liver quality traits of the overfed interspecific hybrid mule duck.
MedLine Citation:
PMID:  23148259     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The mule duck, an interspecific hybrid obtained by crossing common duck (Anas Platyrhynchos) females with Muscovy (Cairina moschata) drakes, is widely used for fatty liver production. The purpose of the present study was to detect and map single and pleiotropic QTL that segregate in the common duck species, and influence the expression of traits in their overfed mule duck offspring. To this end, we generated a common duck back-cross (BC) population by crossing Kaiya and heavy Pekin experimental lines, which differ notably in regard to the bodyweight and overfeeding ability of their mule progeny. The BC females were mated to Muscovy drakes and on average, 4 male mule ducks hatched per BC female (1600 in total) and were measured for growth, metabolism during growth and the overfeeding period, overfeeding ability and the quality of their breast meat and fatty liver. The phenotypic value of BC females was estimated for each trait by assigning to each female the mean value of the phenotypes of her offspring. Estimations allowed for variance, which depended on the number of male offspring per BC and the heritability of the trait considered. The genetic map used for QTL detection consisted of 91 microsatellite markers aggregated into 16 linkage groups (LG) covering a total of 778 cM.Twenty-two QTL were found to be significant at the 1% chromosome-wide threshold level using the single trait detection option of the QTLMap software. Most of the QTL detected were related to the quality of breast meat and fatty liver: QTL for meat pH 20 minutes post mortem were mapped to LG4 (at the 1% genome-wide significance level) and QTL for meat lipid content and cooking losses were mapped to LG2a. QTL related to fatty liver weight and liver protein and lipid content were for the most part detected on LG2c and LG9. Multi-trait analysis highlighted the pleiotropic effects of QTL in these chromosome regions. Apart from the strong QTL for plasma triglyceride content at the end of overfeeding period mapped to chromosome Z using single trait analysis, all metabolic trait QTL were detected with the multi-trait approach: the QTL mapped to LG14 and LG21 affected the plasma cholesterol and triglyceride contents whereas the QTL mapped to LG2a seemed to impact glycemia and the basal plasma corticosterone content. A higher density genetic map will be needed to further fine map the QTL.
Authors:
M Kileh-Wais; J M Elsen; A Vignal; K Feves; F Vignoles; X Fernandez; H Manse; S Davail; J M André; D Bastianelli; L Bonnal; O Filangi; E Baéza; D Guéméné; C Genêt; M D Bernadet; F Dubos; C Marie-Etancelin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Journal of animal science     Volume:  -     ISSN:  1525-3163     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institut National de la Recherche Agronomique, SAGA Station d'Amélioration Génétique des Animaux, UR631, 31 326 Castanet Tolosan, France.
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